NRCAM
neuronal cell adhesion molecule
Summary
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants131 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs372883632 | 7:107,790,381 | C/T | — | uncertain significance |
| rs74708699 | 7:107,790,417 | C/T | — | benign |
| rs777609344 | 7:107,790,486 | C/A | — | uncertain significance |
| rs370347834 | 7:107,790,488 | C/T | — | uncertain significance |
| rs2536417775 | 7:107,790,503 | A/G | — | uncertain significance |
| rs483352709 | 7:107,790,506 | A/C | — | uncertain significance |
| rs62001038 | 7:107,790,526 | T/C | — | benign |
| rs753564364 | 7:107,790,554 | C/T | — | uncertain significance |
| rs759779206 | 7:107,790,577 | G/T | — | uncertain significance |
| rs143224679 | 7:107,797,354 | T/C | regulatory region variant | — |
| rs145828112 | 7:107,799,979 | T/C | — | likely benign |
| rs1224811138 | 7:107,800,798 | T/C | — | likely benign |
| rs2538029126 | 7:107,800,817 | C/T | — | uncertain significance |
| rs2048185763 | 7:107,800,866 | G/A | — | uncertain significance |
| rs1247614027 | 7:107,800,904 | T/C | — | uncertain significance |
| rs760222116 | 7:107,800,914 | T/A | — | uncertain significance |
| rs375339108 | 7:107,800,926 | G/A | — | uncertain significance |
| rs1428967855 | 7:107,807,422 | C/A | — | uncertain significance |
| rs374338191 | 7:107,807,479 | C/T | — | uncertain significance |
| rs200800851 | 7:107,807,482 | G/A | — | uncertain significance |
| rs1585961253 | 7:107,808,769 | T/G | — | uncertain significance |
| rs182113726 | 7:107,808,776 | C/T | — | uncertain significance |
| rs150073322 | 7:107,812,961 | G/A | — | — |
| rs149639654 | 7:107,817,029 | G/A | — | likely benign |
| rs144412712 | 7:107,817,031 | C/T | — | uncertain significance |
| rs1396682274 | 7:107,818,453 | T/C | — | uncertain significance |
| rs143805055 | 7:107,818,484 | C/T | — | likely benign |
| rs899988401 | 7:107,818,507 | G/A | — | uncertain significance |
| rs2061634923 | 7:107,818,542 | G/A | — | uncertain significance |
| rs199867432 | 7:107,820,723 | T/C | — | uncertain significance |
| rs2153275538 | 7:107,820,733 | G/A | — | pathogenic |
| rs377707274 | 7:107,820,771 | G/A | — | uncertain significance |
| rs749220627 | 7:107,820,773 | C/A | — | uncertain significance |
| rs2062777274 | 7:107,820,780 | C/T | — | pathogenic |
| rs139634064 | 7:107,820,813 | T/G | — | uncertain significance |
| rs1488316175 | 7:107,820,817 | T/C | — | uncertain significance |
| rs34721383 | 7:107,820,819 | T/C | — | likely benign |
| rs151029926 | 7:107,820,828 | C/T | — | uncertain significance |
| rs1298979445 | 7:107,820,873 | T/C | — | pathogenic |
| rs746161292 | 7:107,822,267 | C/T | — | uncertain significance |
| rs1490226609 | 7:107,822,303 | G/C | — | uncertain significance |
| rs867372071 | 7:107,822,331 | A/C | — | uncertain significance |
| rs758227136 | 7:107,822,340 | T/C | — | likely benign |
| rs140960250 | 7:107,822,351 | A/G | — | uncertain significance |
| rs557294509 | 7:107,822,354 | C/T | — | likely benign |
| rs150373689 | 7:107,822,355 | G/A | — | uncertain significance |
| rs553748314 | 7:107,822,376 | T/C | — | uncertain significance |
| rs2142325 | 7:107,822,396 | G/A | — | benign |
| rs1398744154 | 7:107,823,150 | G/A | — | uncertain significance |
| rs201534122 | 7:107,823,258 | G/C | — | uncertain significance |
| rs775849144 | 7:107,824,692 | G/A | — | uncertain significance |
| rs145997635 | 7:107,824,700 | C/T | — | likely benign |
| rs2065477733 | 7:107,824,893 | T/A | — | uncertain significance |
| rs372395960 | 7:107,824,917 | C/T | — | uncertain significance |
| rs751120320 | 7:107,824,969 | G/T | — | uncertain significance |
| rs530421155 | 7:107,825,020 | C/A | — | uncertain significance |
| rs1586948354 | 7:107,825,041 | C/T | — | uncertain significance |
| rs1031328372 | 7:107,825,051 | G/T | — | likely benign |
| rs180697830 | 7:107,825,066 | C/T | — | likely benign |
| rs111616050 | 7:107,830,092 | T/C | — | likely benign |
| rs144286716 | 7:107,832,220 | T/C | — | uncertain significance |
| rs112465984 | 7:107,832,232 | G/A | — | uncertain significance |
| rs142274702 | 7:107,834,476 | A/G | — | likely benign |
| rs6958498 | 7:107,834,613 | C/G | — | benign |
| rs6978315 | 7:107,834,624 | T/C | — | benign |
| rs1563368639 | 7:107,834,731 | C/G | — | uncertain significance |
| rs404287 | 7:107,834,734 | C/T | — | benign |
| rs374383279 | 7:107,834,760 | C/A | — | uncertain significance |
| rs779192426 | 7:107,834,789 | T/A | — | uncertain significance |
| rs754306904 | 7:107,834,806 | C/G | — | uncertain significance |
| rs116499789 | 7:107,834,852 | C/T | — | uncertain significance |
| rs143036997 | 7:107,834,856 | C/T | — | uncertain significance |
| rs763576603 | 7:107,834,859 | T/G | — | uncertain significance |
| rs138146461 | 7:107,836,209 | C/T | — | uncertain significance |
| rs771358930 | 7:107,836,215 | T/C | — | uncertain significance |
| rs201033539 | 7:107,836,262 | T/C | — | pathogenic |
| rs115891479 | 7:107,836,311 | G/C | — | likely benign |
| rs2544951039 | 7:107,838,427 | G/C | — | uncertain significance |
| rs2544953064 | 7:107,838,439 | A/G | — | uncertain significance |
| rs559209446 | 7:107,838,537 | G/A | — | uncertain significance |
| rs142366452 | 7:107,848,032 | T/G | — | benign |
| rs748173996 | 7:107,848,100 | G/A | — | uncertain significance |
| rs200568981 | 7:107,848,103 | G/A | — | uncertain significance |
| rs547014629 | 7:107,849,861 | A/G | — | benign |
| rs1011155665 | 7:107,849,882 | A/G | — | uncertain significance |
| rs1395306790 | 7:107,849,961 | T/G | — | uncertain significance |
| rs139922949 | 7:107,866,089 | C/T | missense variant | — |
| rs2093426366 | 7:107,866,687 | T/A | — | uncertain significance |
| rs759601035 | 7:107,866,702 | T/A | — | uncertain significance |
| rs2547249080 | 7:107,866,729 | T/A | — | uncertain significance |
| rs752888953 | 7:107,866,733 | C/T | — | uncertain significance |
| rs764475322 | 7:107,866,735 | C/T | — | uncertain significance |
| rs2547251580 | 7:107,866,768 | A/C | — | uncertain significance |
| rs772993703 | 7:107,866,783 | C/T | — | pathogenic |
| rs746776922 | 7:107,866,787 | G/C | — | uncertain significance |
| rs1180944901 | 7:107,866,804 | T/C | — | uncertain significance |
| rs895722418 | 7:107,871,520 | G/A | — | uncertain significance |
| rs2153741176 | 7:107,872,797 | A/G | — | conflicting classifications of pathogenicity |
| rs2094442812 | 7:107,872,835 | T/A | — | uncertain significance |
| rs140770274 | 7:107,872,866 | C/A | — | pathogenic |
Showing 100 of 131 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.