NRP2

neuropilin 2

Summary

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

Known Variants183 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs114224696	2:206,546,399	G/C	upstream gene variant	—
rs373490681	2:206,548,055	A/T	—	uncertain significance
rs145169333	2:206,548,069	C/G	—	likely benign
rs849530	2:206,555,804	C/A	intron variant	—
rs766763562	2:206,562,275	G/A	—	likely benign
rs1313539710	2:206,562,279	G/A	—	uncertain significance
rs752149340	2:206,562,286	G/A	—	uncertain significance
rs2228643	2:206,562,317	C/T	—	benign
rs746895763	2:206,562,323	C/T	—	likely benign
rs770083351	2:206,562,344	C/G	—	likely benign
rs762216540	2:206,562,360	G/A	—	uncertain significance
rs1275737785	2:206,562,362	G/A	—	likely benign
rs183290527	2:206,562,374	C/T	—	likely benign
rs759206542	2:206,562,380	C/T	—	likely benign
rs764826189	2:206,562,381	G/A	—	uncertain significance
rs375884844	2:206,562,385	C/T	—	uncertain significance
rs1435124991	2:206,562,428	C/T	—	likely benign
rs187417335	2:206,562,454	C/T	—	likely benign
rs370338287	2:206,562,455	G/A	—	likely benign
rs2468966371	2:206,580,927	A/G	—	uncertain significance
rs2056892079	2:206,580,969	G/A	—	uncertain significance
rs757792703	2:206,581,002	A/G	—	uncertain significance
rs756496733	2:206,581,019	C/T	—	likely benign
rs849541	2:206,581,033	G/G	—	benign
rs772877594	2:206,581,052	C/A	—	benign
rs150835990	2:206,581,083	G/C	—	uncertain significance
rs764261615	2:206,581,085	G/A	—	likely benign
rs201391637	2:206,581,107	G/T	—	likely benign
rs547293929	2:206,587,238	A/T	—	uncertain significance
rs34980616	2:206,587,240	G/C	—	uncertain significance
rs765709071	2:206,587,322	T/A	—	uncertain significance
rs150011205	2:206,587,327	A/G	—	likely benign
rs141359798	2:206,587,386	G/C	—	likely benign
rs1480809144	2:206,587,417	G/A	—	uncertain significance
rs532796522	2:206,588,514	C/A	—	uncertain significance
rs1487432984	2:206,588,540	C/T	—	likely benign
rs201324375	2:206,588,560	G/A	—	likely benign
rs138033888	2:206,588,569	C/T	—	uncertain significance
rs2228642	2:206,588,570	G/A	—	benign
rs772945520	2:206,588,606	G/A	—	likely benign
rs370384347	2:206,588,629	C/T	—	likely benign
rs199881632	2:206,588,632	G/A	—	uncertain significance
rs200740591	2:206,588,654	G/A	—	likely benign
rs79750907	2:206,590,654	C/T	—	likely benign
rs377035589	2:206,590,666	G/A	—	uncertain significance
rs771278601	2:206,590,675	C/T	—	uncertain significance
rs114305456	2:206,590,676	G/A	—	benign
rs2228639	2:206,590,686	C/T	—	benign
rs368857132	2:206,590,720	G/A	—	uncertain significance
rs369347008	2:206,590,721	G/A	—	uncertain significance
rs2469013837	2:206,590,730	C/A	—	uncertain significance
rs151124318	2:206,590,778	A/T	—	benign
rs371668549	2:206,590,787	C/G	—	uncertain significance
rs373338064	2:206,592,606	A/C	—	likely benign
rs770873685	2:206,592,620	C/T	—	likely benign
rs114144673	2:206,592,624	C/T	—	uncertain significance
rs769522962	2:206,592,625	G/A	—	uncertain significance
rs150064130	2:206,592,643	C/T	—	uncertain significance
rs762365618	2:206,592,665	G/A	—	likely benign
rs376340891	2:206,592,683	G/C	—	uncertain significance
rs149039089	2:206,592,686	T/G	—	likely benign
rs849526	2:206,592,695	C/T	—	benign
rs903451335	2:206,592,769	A/G	—	uncertain significance
rs183355317	2:206,592,777	C/T	—	likely benign
rs139742739	2:206,605,234	A/G	—	likely benign
rs371862574	2:206,605,235	C/T	—	likely benign
rs144509196	2:206,605,245	A/G	—	benign
rs141715769	2:206,605,260	C/T	—	likely benign
rs1398387715	2:206,605,275	G/A	—	likely benign
rs376163510	2:206,605,293	C/T	—	likely benign
rs1384781458	2:206,605,295	C/G	—	uncertain significance
rs778106244	2:206,605,358	G/A	—	uncertain significance
rs139711818	2:206,605,378	C/T	—	uncertain significance
rs551278469	2:206,607,956	C/T	—	likely benign
rs201900948	2:206,607,968	A/C	—	likely benign
rs2057476882	2:206,608,044	G/C	—	uncertain significance
rs746710925	2:206,608,046	C/G	—	uncertain significance
rs149849497	2:206,608,047	G/A	—	uncertain significance
rs529980618	2:206,608,051	G/A	—	likely benign
rs141076137	2:206,608,084	C/T	—	benign
rs762753258	2:206,608,085	G/A	—	likely benign
rs143148436	2:206,608,090	G/A	—	likely benign
rs2057478636	2:206,608,102	G/A	—	likely benign
rs375155400	2:206,608,103	G/C	—	uncertain significance
rs182060947	2:206,608,157	G/A	—	likely benign
rs1363511821	2:206,608,176	C/T	—	uncertain significance
rs138817280	2:206,608,198	G/A	—	likely benign
rs753882233	2:206,608,200	G/A	—	uncertain significance
rs373025184	2:206,608,228	C/T	—	likely benign
rs758760273	2:206,608,233	A/G	—	uncertain significance
rs1302053333	2:206,608,244	T/C	—	uncertain significance
rs761804910	2:206,608,300	G/T	—	likely benign
rs113407305	2:206,608,304	C/T	—	likely benign
rs572474850	2:206,608,305	G/A	—	likely benign
rs849563	2:206,610,502	T/G	synonymous variant	benign
rs766899842	2:206,610,510	G/A	—	uncertain significance
rs759744241	2:206,610,513	G/A	—	uncertain significance
rs757643027	2:206,610,543	G/A	—	uncertain significance
rs767989880	2:206,610,547	A/G	—	likely benign
rs778602865	2:206,610,553	G/A	—	likely benign

Showing 100 of 183 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.