NUAK2
NUAK family kinase 2
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Located in nuclear speck. Implicated in anencephaly. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs759555031 | 1:205,272,597 | A/C | — | uncertain significance |
| rs373396807 | 1:205,272,679 | G/C | — | uncertain significance |
| rs148583611 | 1:205,272,732 | G/A | — | likely benign |
| rs904663970 | 1:205,272,738 | T/C | — | uncertain significance |
| rs774383116 | 1:205,272,792 | T/A | — | uncertain significance |
| rs549855734 | 1:205,272,852 | C/T | — | uncertain significance |
| rs753584463 | 1:205,272,882 | G/T | — | uncertain significance |
| rs568637332 | 1:205,272,919 | C/T | — | likely benign |
| rs1429208628 | 1:205,272,930 | G/A | — | uncertain significance |
| rs139426041 | 1:205,272,949 | C/T | — | uncertain significance |
| rs1106202 | 1:205,272,983 | C/G | synonymous variant | — |
| rs56069742 | 1:205,273,040 | G/A | — | benign |
| rs114413074 | 1:205,273,076 | G/A | — | likely benign |
| rs767244934 | 1:205,273,273 | G/C | — | uncertain significance |
| rs539524885 | 1:205,273,368 | G/T | — | uncertain significance |
| rs756497760 | 1:205,273,444 | G/A | — | uncertain significance |
| rs200343978 | 1:205,273,456 | G/A | — | uncertain significance |
| rs2464691045 | 1:205,273,470 | A/G | — | uncertain significance |
| rs1574889744 | 1:205,273,498 | G/A | — | uncertain significance |
| rs2464691185 | 1:205,273,513 | G/A | — | uncertain significance |
| rs374937005 | 1:205,273,515 | G/A | — | likely benign |
| rs200627742 | 1:205,273,536 | C/T | — | uncertain significance |
| rs760947538 | 1:205,273,596 | C/T | — | uncertain significance |
| rs766695858 | 1:205,273,597 | G/A | — | uncertain significance |
| rs2464695710 | 1:205,275,345 | C/T | — | uncertain significance |
| rs749723966 | 1:205,275,423 | C/T | — | uncertain significance |
| rs767982138 | 1:205,277,807 | C/T | — | uncertain significance |
| rs138824143 | 1:205,277,812 | C/T | — | uncertain significance |
| rs115768136 | 1:205,277,813 | G/A | — | likely benign |
| rs752222690 | 1:205,280,862 | T/C | — | uncertain significance |
| rs1350662592 | 1:205,280,875 | T/A | — | uncertain significance |
| rs773539973 | 1:205,280,925 | T/C | — | uncertain significance |
| rs770212647 | 1:205,290,564 | C/T | — | uncertain significance |
| rs906845965 | 1:205,290,626 | T/C | — | uncertain significance |
| rs760713380 | 1:205,290,646 | C/A | — | uncertain significance |
| rs1322860239 | 1:205,290,674 | A/T | — | uncertain significance |
| rs1288980920 | 1:205,290,676 | C/T | — | likely benign |
| rs2464723303 | 1:205,290,746 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.