NUDT3
nudix hydrolase 3
Summary
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1431997363 | 6:34,256,538 | T/A | — | uncertain significance |
| rs3798556 | 6:34,294,006 | G/C | intron variant | — |
| rs115546868 | 6:34,297,585 | C/T | intron variant | — |
| rs206936 | 6:34,302,869 | A/G | regulatory region variant | — |
| rs7775497 | 6:34,305,251 | C/T | intron variant | — |
| rs2237098 | 6:34,305,897 | C/G | — | — |
| rs464553 | 6:34,315,079 | G/C | — | — |
| rs183578586 | 6:34,321,061 | T/C | intron variant | — |
| rs193135027 | 6:34,329,768 | T/C | intron variant | — |
| rs11967909 | 6:34,329,804 | T/C | intron variant | — |
| rs7738445 | 6:34,330,272 | A/C | intron variant | — |
| rs206925 | 6:34,339,982 | T/G | — | — |
| rs206920 | 6:34,349,799 | A/G | intron variant | — |
| rs547100994 | 6:34,360,075 | G/C | — | uncertain significance |
| rs776066611 | 6:34,360,123 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.