NXPE3
neurexophilin and PC-esterase domain family member 3
Summary
This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs17412601 | 3:101,499,275 | T/A | — | — |
| rs150533214 | 3:101,504,517 | A/G | — | uncertain significance |
| rs11706494 | 3:101,509,475 | A/T | intron variant | — |
| rs11712309 | 3:101,519,097 | T/C | intron variant | — |
| rs1045786849 | 3:101,520,143 | A/G | — | uncertain significance |
| rs551278520 | 3:101,520,158 | G/A | — | uncertain significance |
| rs2545901977 | 3:101,520,196 | T/C | — | uncertain significance |
| rs751813349 | 3:101,520,208 | C/T | — | uncertain significance |
| rs267599518 | 3:101,520,271 | C/T | — | uncertain significance |
| rs370390072 | 3:101,520,292 | C/G | — | uncertain significance |
| rs1045411888 | 3:101,520,333 | C/A | — | uncertain significance |
| rs1363350994 | 3:101,520,391 | C/G | — | uncertain significance |
| rs1359984713 | 3:101,520,421 | G/C | — | uncertain significance |
| rs2545903315 | 3:101,520,479 | A/G | — | uncertain significance |
| rs2545903717 | 3:101,520,604 | A/G | — | uncertain significance |
| rs1235758990 | 3:101,520,607 | G/A | — | uncertain significance |
| rs772461123 | 3:101,520,742 | A/G | — | uncertain significance |
| rs1941180403 | 3:101,520,764 | G/C | — | uncertain significance |
| rs201056771 | 3:101,520,777 | C/G | — | uncertain significance |
| rs140150886 | 3:101,535,672 | G/C | — | benign |
| rs376234770 | 3:101,540,317 | A/G | — | uncertain significance |
| rs149452985 | 3:101,540,335 | G/T | — | uncertain significance |
| rs143967067 | 3:101,540,355 | C/T | — | uncertain significance |
| rs2472038365 | 3:101,540,386 | A/G | — | likely benign |
| rs548864461 | 3:101,540,436 | G/A | — | uncertain significance |
| rs781572583 | 3:101,540,490 | C/T | — | uncertain significance |
| rs374457110 | 3:101,540,494 | G/A | — | uncertain significance |
| rs200277463 | 3:101,540,509 | G/C | — | uncertain significance |
| rs1387957344 | 3:101,540,643 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.