ODAPH

odontogenesis associated phosphoprotein

Summary

Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]

Known Variants19 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5478846994:76,479,353G/A
rs68476234:76,480,948A/Gbenign
rs68539654:76,481,051T/Cbenign
rs7549901684:76,481,346A/Tlikely benign
rs172143574:76,481,497G/Abenign
rs172143924:76,481,575A/Cbenign
rs623186564:76,481,628A/Cbenign
rs170006474:76,481,730C/T
rs24763339784:76,481,804T/Glikely benign
rs15605626304:76,489,322A/Tpathogenic
rs23061754:76,489,345C/Tbenign
rs1433197064:76,489,374G/Tlikely benign
rs15605627384:76,489,385C/Apathogenic
rs7693192244:76,489,448C/Tuncertain significance
rs8669415364:76,489,485C/Tpathogenic
rs1407563904:76,489,533T/Cbenign
rs1466453814:76,489,574G/Amissense variantpathogenic
rs23061744:76,489,582G/Abenign
rs1887356834:76,489,722C/Tlikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.