OGFR
opioid growth factor receptor
Summary
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200688146 | 20:61,438,881 | C/G | — | likely benign |
| rs557578457 | 20:61,439,630 | C/T | — | likely benign |
| rs373508388 | 20:61,440,970 | C/T | — | uncertain significance |
| rs1990702568 | 20:61,441,916 | A/G | — | uncertain significance |
| rs148694509 | 20:61,442,943 | C/T | — | uncertain significance |
| rs1157953260 | 20:61,443,602 | G/C | — | uncertain significance |
| rs777605843 | 20:61,443,698 | G/A | — | likely benign |
| rs377251680 | 20:61,443,725 | C/T | — | uncertain significance |
| rs754513274 | 20:61,443,758 | G/A | — | uncertain significance |
| rs200108407 | 20:61,443,809 | G/A | missense variant | — |
| rs1403207213 | 20:61,443,838 | A/G | — | uncertain significance |
| rs775000313 | 20:61,443,901 | G/A | — | uncertain significance |
| rs752869904 | 20:61,443,932 | A/C | — | uncertain significance |
| rs200386552 | 20:61,443,949 | C/G | — | uncertain significance |
| rs1449766219 | 20:61,443,968 | A/G | — | likely benign |
| rs1200076900 | 20:61,444,010 | G/A | — | uncertain significance |
| rs1990761713 | 20:61,444,040 | T/C | — | uncertain significance |
| rs780644005 | 20:61,444,047 | G/C | — | uncertain significance |
| rs772801234 | 20:61,444,075 | G/A | — | uncertain significance |
| rs374043529 | 20:61,444,088 | C/T | — | uncertain significance |
| rs780226718 | 20:61,444,121 | G/A | — | uncertain significance |
| rs201013679 | 20:61,444,139 | G/A | — | uncertain significance |
| rs564432812 | 20:61,444,198 | G/A | — | uncertain significance |
| rs375174582 | 20:61,444,414 | G/A | — | uncertain significance |
| rs2516007228 | 20:61,444,460 | A/G | — | uncertain significance |
| rs373481743 | 20:61,444,486 | C/G | — | uncertain significance |
| rs747201389 | 20:61,444,487 | G/A | — | likely benign |
| rs768751413 | 20:61,444,490 | C/T | — | uncertain significance |
| rs1487402920 | 20:61,444,568 | C/T | — | uncertain significance |
| rs3210217 | 20:61,444,605 | A/G | — | likely benign |
| rs551254702 | 20:61,444,656 | C/A | — | likely benign |
| rs1391314465 | 20:61,444,681 | G/C | — | uncertain significance |
| rs752820010 | 20:61,444,683 | C/T | — | likely benign |
| rs778114767 | 20:61,444,694 | A/C | — | uncertain significance |
| rs200135858 | 20:61,444,707 | G/C | — | uncertain significance |
| rs74520364 | 20:61,444,725 | G/A | — | likely benign |
| rs202064940 | 20:61,444,743 | T/C | — | likely benign |
| rs201144213 | 20:61,444,763 | C/T | — | conflicting classifications of pathogenicity |
| rs1225477474 | 20:61,444,792 | C/T | — | uncertain significance |
| rs529335569 | 20:61,444,803 | C/T | — | likely benign |
| rs562078272 | 20:61,444,805 | A/C | — | uncertain significance |
| rs1178049268 | 20:61,444,823 | C/T | — | uncertain significance |
| rs544644237 | 20:61,444,837 | C/T | — | uncertain significance |
| rs961395539 | 20:61,444,844 | C/T | — | uncertain significance |
| rs1390742574 | 20:61,444,897 | C/A | — | uncertain significance |
| rs769480850 | 20:61,444,904 | C/T | — | uncertain significance |
| rs141172367 | 20:61,444,923 | T/C | — | likely benign |
| rs762011771 | 20:61,444,930 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.