OSCAR

osteoclast associated Ig-like receptor

Summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Known Variants31 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11782934919:54,598,236G/A3 prime UTR variant
rs124581475419:54,599,017C/Guncertain significance
rs20060817719:54,599,028G/Auncertain significance
rs95546034919:54,599,085G/Tuncertain significance
rs76976789419:54,599,089C/Tuncertain significance
rs251583729019:54,599,148A/Guncertain significance
rs19990961019:54,599,286G/Auncertain significance
rs75107755919:54,599,287G/Auncertain significance
rs132501865219:54,599,292G/Auncertain significance
rs139859014519:54,599,293C/Auncertain significance
rs120196568819:54,599,310A/Tuncertain significance
rs74999607419:54,599,313A/Glikely benign
rs14296485219:54,599,314C/Gmissense variant
rs77212741519:54,599,315G/Cuncertain significance
rs74823355419:54,599,334C/Tuncertain significance
rs77115291119:54,599,347G/Tuncertain significance
rs58766737019:54,599,352C/Tuncertain significance
rs75996265419:54,599,356C/Auncertain significance
rs207267173119:54,599,364C/Tuncertain significance
rs99409462819:54,599,416C/Tuncertain significance
rs76922335119:54,600,214C/Auncertain significance
rs251585801719:54,600,304A/Glikely benign
rs127209880019:54,600,311C/Auncertain significance
rs207278138319:54,600,351T/Auncertain significance
rs75628195519:54,600,370A/Cuncertain significance
rs11384020419:54,600,378G/Cuncertain significance
rs77525899719:54,600,448G/Auncertain significance
rs58773420619:54,601,163T/C
rs20100044319:54,603,044G/Auncertain significance
rs77494166219:54,603,056G/Auncertain significance
rs58771144119:54,603,349C/T

Gene information from NCBI Gene. Variant classifications from ClinVar.