OSCAR
osteoclast associated Ig-like receptor
Summary
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs117829349 | 19:54,598,236 | G/A | 3 prime UTR variant | — |
| rs1245814754 | 19:54,599,017 | C/G | — | uncertain significance |
| rs200608177 | 19:54,599,028 | G/A | — | uncertain significance |
| rs955460349 | 19:54,599,085 | G/T | — | uncertain significance |
| rs769767894 | 19:54,599,089 | C/T | — | uncertain significance |
| rs2515837290 | 19:54,599,148 | A/G | — | uncertain significance |
| rs199909610 | 19:54,599,286 | G/A | — | uncertain significance |
| rs751077559 | 19:54,599,287 | G/A | — | uncertain significance |
| rs1325018652 | 19:54,599,292 | G/A | — | uncertain significance |
| rs1398590145 | 19:54,599,293 | C/A | — | uncertain significance |
| rs1201965688 | 19:54,599,310 | A/T | — | uncertain significance |
| rs749996074 | 19:54,599,313 | A/G | — | likely benign |
| rs142964852 | 19:54,599,314 | C/G | missense variant | — |
| rs772127415 | 19:54,599,315 | G/C | — | uncertain significance |
| rs748233554 | 19:54,599,334 | C/T | — | uncertain significance |
| rs771152911 | 19:54,599,347 | G/T | — | uncertain significance |
| rs587667370 | 19:54,599,352 | C/T | — | uncertain significance |
| rs759962654 | 19:54,599,356 | C/A | — | uncertain significance |
| rs2072671731 | 19:54,599,364 | C/T | — | uncertain significance |
| rs994094628 | 19:54,599,416 | C/T | — | uncertain significance |
| rs769223351 | 19:54,600,214 | C/A | — | uncertain significance |
| rs2515858017 | 19:54,600,304 | A/G | — | likely benign |
| rs1272098800 | 19:54,600,311 | C/A | — | uncertain significance |
| rs2072781383 | 19:54,600,351 | T/A | — | uncertain significance |
| rs756281955 | 19:54,600,370 | A/C | — | uncertain significance |
| rs113840204 | 19:54,600,378 | G/C | — | uncertain significance |
| rs775258997 | 19:54,600,448 | G/A | — | uncertain significance |
| rs587734206 | 19:54,601,163 | T/C | — | — |
| rs201000443 | 19:54,603,044 | G/A | — | uncertain significance |
| rs774941662 | 19:54,603,056 | G/A | — | uncertain significance |
| rs587711441 | 19:54,603,349 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.