P2RY11
purinergic receptor P2Y11
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12460842 | 19:10,222,195 | A/G | — | association |
| rs73011214 | 19:10,222,205 | G/T | — | — |
| rs140237295 | 19:10,222,410 | G/A | — | benign |
| rs748234227 | 19:10,224,469 | A/G | — | likely benign |
| rs760333567 | 19:10,224,487 | C/A | — | likely benign |
| rs753346854 | 19:10,224,496 | C/A | — | likely benign |
| rs757328124 | 19:10,224,539 | C/T | — | uncertain significance |
| rs145464312 | 19:10,224,547 | C/T | — | likely benign |
| rs3745601 | 19:10,224,548 | A/G | — | benign |
| rs142196416 | 19:10,224,619 | C/T | — | benign |
| rs139151367 | 19:10,224,629 | C/T | — | likely benign |
| rs79800334 | 19:10,224,637 | C/T | — | benign |
| rs1599321205 | 19:10,224,694 | C/T | — | likely benign |
| rs112371201 | 19:10,224,785 | A/G | — | likely benign |
| rs139489816 | 19:10,224,844 | C/T | — | likely benign |
| rs115986278 | 19:10,224,937 | G/A | — | benign |
| rs774978141 | 19:10,224,964 | C/T | — | likely benign |
| rs138801877 | 19:10,224,973 | C/T | — | likely benign |
| rs145891760 | 19:10,225,012 | C/T | — | likely benign |
| rs77496977 | 19:10,225,060 | C/T | — | benign |
| rs147836890 | 19:10,225,115 | C/T | — | likely benign |
| rs111752629 | 19:10,225,138 | G/A | — | likely benign |
| rs146974153 | 19:10,225,189 | C/G | — | likely benign |
| rs62638736 | 19:10,225,308 | A/G | — | benign |
| rs147132685 | 19:10,225,381 | G/A | — | likely benign |
| rs74462278 | 19:10,225,390 | C/G | — | benign |
| rs2305795 | 19:10,226,052 | G/A | regulatory region variant | association |
Gene information from NCBI Gene. Variant classifications from ClinVar.