PANK4

pantothenate kinase 4 (inactive)

Summary

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

Known Variants43 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5285817531:2,440,403G/Alikely benign
rs16436153891:2,440,452T/Auncertain significance
rs5350924131:2,441,308C/Tuncertain significance
rs3754307381:2,441,500C/Tuncertain significance
rs9758381281:2,441,517G/Auncertain significance
rs25230526711:2,442,125C/Guncertain significance
rs7601446161:2,442,134G/Cuncertain significance
rs25230527631:2,442,142C/Tuncertain significance
rs7525615651:2,442,206A/Cuncertain significance
rs21007737411:2,444,352C/Tuncertain significance
rs25230654561:2,444,408C/Tuncertain significance
rs75355281:2,444,414A/Gbenign
rs3726815431:2,444,415C/Auncertain significance
rs1416229011:2,444,426C/Tuncertain significance
rs7601212691:2,444,427G/Auncertain significance
rs3705572541:2,444,457C/Tuncertain significance
rs16437202081:2,445,811G/Auncertain significance
rs7503067321:2,447,057C/Tuncertain significance
rs1438637161:2,447,082G/Alikely benign
rs1503077351:2,447,091C/Tlikely benign
rs3749925621:2,449,613C/Tuncertain significance
rs1508590291:2,449,619C/Tuncertain significance
rs7506034871:2,449,628G/Auncertain significance
rs1426388621:2,449,629G/Tuncertain significance
rs1500937841:2,449,653T/Auncertain significance
rs7649003931:2,450,664C/Tuncertain significance
rs1996076921:2,451,257G/Cuncertain significance
rs347246501:2,451,298G/Alikely benign
rs9872919471:2,451,347T/Cuncertain significance
rs12929447781:2,451,380A/Guncertain significance
rs5752000841:2,451,906C/Tpathogenic
rs1381407031:2,452,188T/Cuncertain significance
rs16438689201:2,452,278G/Tuncertain significance
rs7759546901:2,452,296C/Tuncertain significance
rs11976679341:2,452,547G/Auncertain significance
rs29858621:2,452,569T/Cbenign
rs16438720951:2,452,618G/Cuncertain significance
rs7616847921:2,452,666G/Auncertain significance
rs7453654261:2,452,748C/Guncertain significance
rs1407955731:2,452,750G/Auncertain significance
rs120735041:2,452,979C/Gintron variant
rs7685779351:2,453,161C/Auncertain significance
rs7608758921:2,458,007C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.