PARN

poly(A)-specific ribonuclease

Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Known Variants647 total

rsidPosition (GRCh37)AllelesClassClinVar
rs196071626616:14,530,578C/T—uncertain significance
rs117176114716:14,530,579A/G—uncertain significance
rs76521383016:14,530,580T/C—likely benign
rs118708694016:14,530,583G/T—uncertain significance
rs75072113416:14,530,594C/T—uncertain significance
rs196071874916:14,530,599A/C—uncertain significance
rs36920867516:14,530,602G/C—uncertain significance
rs20067708916:14,530,603T/C—uncertain significance
rs75593231716:14,530,607A/G—likely benign
rs77780618616:14,530,613G/C—uncertain significance
rs37009057216:14,530,619C/T—likely benign
rs20196303216:14,530,620G/A—conflicting classifications of pathogenicity
rs53562725016:14,530,624T/C—uncertain significance
rs156727851816:14,530,629C/T—uncertain significance
rs250645445416:14,530,635G/C—likely benign
rs76887436216:14,530,638A/G—likely benign
rs77724765116:14,530,645A/G—likely benign
rs11363174316:14,530,726G/A—benign
rs74540619216:14,540,725C/T—likely benign
rs77153305416:14,540,726G/A—likely benign
rs250655773516:14,540,731G/A—likely benign
rs215155678216:14,540,736A/G—likely benign
rs137144034116:14,540,740C/A—uncertain significance
rs103544618116:14,540,751G/A—uncertain significance
rs196122316816:14,540,758C/T—likely benign
rs134001288716:14,540,759T/A—uncertain significance
rs36844005216:14,540,766T/C—conflicting classifications of pathogenicity
rs91361712316:14,540,767C/T—uncertain significance
rs196122427316:14,540,768A/G—uncertain significance
rs250655865716:14,540,769T/C—uncertain significance
rs196122437816:14,540,771C/T—uncertain significance
rs136144333816:14,540,774T/C—uncertain significance
rs37273549516:14,540,785G/T—likely benign
rs133126880516:14,540,791T/C—likely benign
rs250655919716:14,540,792T/C—uncertain significance
rs215155689116:14,540,803T/A—likely benign
rs76673154716:14,540,809G/C—likely benign
rs215155691016:14,540,813T/C—uncertain significance
rs75163290016:14,540,818A/G—likely benign
rs159643323916:14,540,820A/G—uncertain significance
rs105183413316:14,540,822G/A—uncertain significance
rs20043414316:14,540,824A/C—uncertain significance
rs76770207416:14,540,826C/A—uncertain significance
rs18755557916:14,540,827G/A—likely benign
rs250655995616:14,540,828G/T—uncertain significance
rs138491204816:14,540,830C/A—uncertain significance
rs52884701516:14,540,836A/C—likely benign
rs97509790816:14,540,841C/G—uncertain significance
rs250656025516:14,540,845G/A—likely benign
rs75024745516:14,540,847C/A—uncertain significance
rs14805294616:14,540,848G/A—likely benign
rs196123034616:14,540,855T/G—uncertain significance
rs196123054216:14,540,858C/T—uncertain significance
rs77969133316:14,540,859C/T—uncertain significance
rs7500707316:14,540,868C/T—benign
rs75443648016:14,540,869G/A—likely benign
rs74857553116:14,540,876A/C—uncertain significance
rs250656130116:14,540,890T/C—likely benign
rs102496957616:14,540,894C/T—uncertain significance
rs250656150416:14,540,902C/A—uncertain significance
rs250656161416:14,540,907T/C—uncertain significance
rs146668368116:14,540,909C/T—uncertain significance
rs156728449816:14,540,912T/C—uncertain significance
rs117869513016:14,540,913T/C—uncertain significance
rs159643362616:14,540,917T/C—likely benign
rs20043377116:14,540,918A/G—uncertain significance
rs3572250416:14,540,919C/T—benign
rs76747143116:14,540,925T/C—uncertain significance
rs250656227416:14,540,931C/T—uncertain significance
rs215155711316:14,540,935A/G—likely benign
rs250656238716:14,540,936A/C—uncertain significance
rs127139880116:14,540,939C/A—likely pathogenic
rs75015758716:14,540,955G/A—likely benign
rs105319711516:14,540,956G/A—likely benign
rs11727561516:14,562,392A/Tupstream gene variant—
rs250691216316:14,576,475T/C—likely benign
rs11642701016:14,576,478C/T—likely benign
rs215159709016:14,576,482T/C—likely benign
rs250691232216:14,576,483G/A—likely benign
rs250691253316:14,576,490C/G—uncertain significance
rs196344539116:14,576,494C/A—likely pathogenic
rs250691272316:14,576,497A/G—likely benign
rs76293064016:14,576,498T/C—uncertain significance
rs37248917116:14,576,504C/T—uncertain significance
rs75454043616:14,576,505G/A—uncertain significance
rs37581387316:14,576,510T/C—uncertain significance
rs96580612916:14,576,511A/G—uncertain significance
rs215159715416:14,576,513T/G—uncertain significance
rs136835020416:14,576,515A/T—uncertain significance
rs250691363516:14,576,520G/A—pathogenic
rs75208257916:14,576,528T/C—uncertain significance
rs37293712616:14,576,530G/C—likely benign
rs77937962216:14,576,535T/G—uncertain significance
rs215159718916:14,576,538A/G—uncertain significance
rs74569659016:14,576,541G/A—pathogenic
rs55075543216:14,576,545G/A—likely benign
rs37719918716:14,576,552C/G—uncertain significance
rs18378102216:14,576,553G/A—uncertain significance
rs250691528116:14,576,565C/T—uncertain significance
rs215159726616:14,576,584A/C—likely benign

Showing 100 of 647 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.