PARP4

poly(ADP-ribose) polymerase family member 4

Summary

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Known Variants118 total

rsidPosition (GRCh37)AllelesClassClinVar
rs76369284613:24,995,295A/G—uncertain significance
rs103574309413:24,995,339G/A—uncertain significance
rs75698770113:24,995,367G/A—uncertain significance
rs19980314513:24,995,392T/C—likely benign
rs124843039513:25,000,698T/A—uncertain significance
rs141267366413:25,005,583C/A—uncertain significance
rs14184293113:25,008,598T/C—uncertain significance
rs76940140013:25,008,634T/C—uncertain significance
rs254226326313:25,008,681T/C—uncertain significance
rs75971352313:25,008,705C/T—uncertain significance
rs78118629813:25,008,729G/A—uncertain significance
rs142029488213:25,008,768G/A—uncertain significance
rs6174195113:25,008,873G/C—likely benign
rs100640235813:25,008,919A/T—uncertain significance
rs14631549413:25,008,966T/C—uncertain significance
rs13923343313:25,008,985G/T—uncertain significance
rs14792445313:25,009,125G/A—uncertain significance
rs75119639413:25,009,155T/A—uncertain significance
rs105222322113:25,009,222C/G—uncertain significance
rs15114543613:25,009,231A/G—uncertain significance
rs141590477013:25,009,281G/A—uncertain significance
rs20064888613:25,009,285G/C—uncertain significance
rs14088673313:25,009,293G/A—uncertain significance
rs37263365313:25,009,317G/A—uncertain significance
rs144212150913:25,009,377A/G—uncertain significance
rs77267427513:25,009,387T/G—uncertain significance
rs55169408813:25,009,395G/A—uncertain significance
rs6173972713:25,009,502T/A—uncertain significance
rs76196009413:25,009,530A/G—uncertain significance
rs76744267213:25,009,531T/C—uncertain significance
rs498682313:25,009,532T/C—benign
rs115941335913:25,009,549G/A—uncertain significance
rs76663134413:25,009,566C/T—uncertain significance
rs119359059413:25,009,612A/C—uncertain significance
rs14310737813:25,015,991C/T—conflicting classifications of pathogenicity
rs5919580813:25,016,008C/T—benign
rs142291411613:25,016,014C/A—uncertain significance
rs147107834813:25,016,025T/C—uncertain significance
rs77938839913:25,016,032C/A—likely benign
rs121001059413:25,016,064C/T—uncertain significance
rs5588861613:25,016,092C/T—benign
rs14539149313:25,016,101C/T—likely benign
rs14252757513:25,016,729C/T—uncertain significance
rs146845867713:25,016,798A/G—uncertain significance
rs77928779913:25,017,789T/C—uncertain significance
rs76791203813:25,017,844C/T—uncertain significance
rs57244469713:25,020,890A/G—uncertain significance
rs131048851113:25,021,179T/C—uncertain significance
rs733458713:25,021,245A/G—benign
rs14010595113:25,021,249C/A—uncertain significance
rs53046095513:25,021,273C/T—uncertain significance
rs254228259113:25,023,884G/T—uncertain significance
rs74809161013:25,023,906C/T—uncertain significance
rs75890653913:25,023,942G/A—uncertain significance
rs74873846113:25,026,577C/T—uncertain significance
rs3468943513:25,026,586T/C—benign
rs75759291613:25,026,594C/G—uncertain significance
rs14263194413:25,026,650G/A—uncertain significance
rs187157906213:25,026,664G/C—uncertain significance
rs75358686913:25,027,743C/T—uncertain significance
rs75813116913:25,027,751T/G—uncertain significance
rs7454343513:25,029,210A/G—benign
rs139446475413:25,029,233G/C—uncertain significance
rs76003378913:25,029,320C/T—uncertain significance
rs15089803913:25,029,336G/A—likely benign
rs77057138013:25,030,544T/C—uncertain significance
rs20057476513:25,030,612G/A—uncertain significance
rs14280047613:25,034,220T/G—uncertain significance
rs7692242013:25,034,237T/G—likely benign
rs187213266413:25,034,244G/T—uncertain significance
rs20134287913:25,043,163G/A—uncertain significance
rs14784092813:25,043,172T/C—uncertain significance
rs254231051113:25,043,211T/G—uncertain significance
rs75742056013:25,043,233C/T—uncertain significance
rs136458706013:25,044,075C/T—uncertain significance
rs37281474613:25,044,138T/C—uncertain significance
rs76607458513:25,049,618C/G—uncertain significance
rs54181847713:25,051,963C/G—uncertain significance
rs116222928313:25,051,967T/C—uncertain significance
rs77386702013:25,052,271T/C—uncertain significance
rs20218641313:25,052,309A/C—uncertain significance
rs56704672113:25,052,342G/A—likely benign
rs75694216913:25,058,831C/T—uncertain significance
rs14584489313:25,058,832G/A—likely benign
rs53574211713:25,058,834C/T—likely benign
rs36958889413:25,058,854C/T—likely benign
rs14279976013:25,058,855G/A—benign
rs133361578513:25,060,345T/C—uncertain significance
rs74722227613:25,060,357C/T—likely benign
rs75744009513:25,060,438C/T—uncertain significance
rs20145690713:25,064,828C/T—uncertain significance
rs19953232213:25,064,916G/T—uncertain significance
rs77994403813:25,066,609G/C—uncertain significance
rs20163541613:25,066,622G/C—uncertain significance
rs132317312013:25,066,627G/T—uncertain significance
rs254234012513:25,066,669C/T—uncertain significance
rs37258634713:25,066,708G/A—uncertain significance
rs13961532013:25,066,714T/C—uncertain significance
rs19985119013:25,067,736C/T—uncertain significance
rs254234138913:25,067,759G/A—uncertain significance

Showing 100 of 118 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.