PARP8
poly(ADP-ribose) polymerase family member 8
Summary
Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs748506179 | 5:49,962,955 | G/A | — | uncertain significance |
| rs12055210 | 5:49,989,701 | A/T | — | — |
| rs282544 | 5:50,026,465 | C/T | intron variant | — |
| rs1382583827 | 5:50,055,558 | T/C | — | uncertain significance |
| rs1184775663 | 5:50,057,701 | A/G | — | uncertain significance |
| rs372370052 | 5:50,058,992 | A/G | — | uncertain significance |
| rs760230087 | 5:50,073,953 | G/A | — | uncertain significance |
| rs74334916 | 5:50,079,603 | A/C | intron variant | — |
| rs778904659 | 5:50,084,379 | G/C | — | uncertain significance |
| rs146551276 | 5:50,084,396 | G/A | — | uncertain significance |
| rs201728056 | 5:50,090,068 | G/T | — | uncertain significance |
| rs141289970 | 5:50,090,094 | A/G | — | likely benign |
| rs2479827759 | 5:50,090,105 | A/T | — | uncertain significance |
| rs182405658 | 5:50,090,122 | G/T | — | uncertain significance |
| rs766923691 | 5:50,090,903 | C/G | — | uncertain significance |
| rs2479836425 | 5:50,091,069 | A/G | — | uncertain significance |
| rs753400508 | 5:50,091,091 | T/C | — | uncertain significance |
| rs147176406 | 5:50,091,204 | C/T | — | uncertain significance |
| rs1438997077 | 5:50,091,207 | A/C | — | uncertain significance |
| rs370470653 | 5:50,091,249 | G/T | — | uncertain significance |
| rs200351181 | 5:50,092,849 | C/T | — | uncertain significance |
| rs1421801606 | 5:50,092,850 | G/A | — | uncertain significance |
| rs188777215 | 5:50,107,941 | A/T | regulatory region variant | — |
| rs778788248 | 5:50,117,159 | C/T | — | uncertain significance |
| rs759633672 | 5:50,124,192 | G/A | — | uncertain significance |
| rs201581623 | 5:50,128,656 | G/A | — | uncertain significance |
| rs1437138665 | 5:50,129,826 | G/A | — | uncertain significance |
| rs756435205 | 5:50,130,816 | A/G | — | uncertain significance |
| rs780325701 | 5:50,137,815 | A/C | — | uncertain significance |
| rs186735992 | 5:50,137,871 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.