PDE12

phosphodiesterase 12

Summary

Enables poly(A)-specific ribonuclease activity. Involved in several processes, including cellular response to interferon-alpha; innate immune response; and mRNA catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3676738373:57,542,137C/Tuncertain significance
rs10082896223:57,542,207C/Tuncertain significance
rs13537246603:57,542,288A/Guncertain significance
rs7816265833:57,542,293A/Guncertain significance
rs20696626933:57,542,312A/Cuncertain significance
rs25309470333:57,542,341G/Auncertain significance
rs1482049453:57,542,348A/Guncertain significance
rs7710173393:57,542,359G/Auncertain significance
rs7641613453:57,542,387A/Guncertain significance
rs2018142533:57,542,485T/Guncertain significance
rs5374584983:57,542,488C/Guncertain significance
rs20696678913:57,542,605C/Guncertain significance
rs20696680213:57,542,609A/Guncertain significance
rs7684637593:57,542,621A/Guncertain significance
rs3713191483:57,542,810A/Guncertain significance
rs7549661643:57,542,834G/Cuncertain significance
rs7711130983:57,542,866G/Alikely benign
rs7518854343:57,542,939C/Auncertain significance
rs10217882163:57,543,039G/Tuncertain significance
rs7692027593:57,543,070G/Cuncertain significance
rs1496180703:57,543,101A/Guncertain significance
rs9746188443:57,543,191T/Guncertain significance
rs7502401993:57,543,283C/Tuncertain significance
rs1497217663:57,543,317C/Tuncertain significance
rs11726863783:57,543,338A/Guncertain significance
rs1419800443:57,543,376G/Auncertain significance
rs5489659753:57,543,403T/Auncertain significance
rs5688291213:57,543,404C/Auncertain significance
rs25309592323:57,545,037G/Cuncertain significance
rs9417591293:57,545,314G/Auncertain significance
rs14611057623:57,545,330C/Tuncertain significance
rs20697082403:57,545,552A/Guncertain significance
rs11976784413:57,545,726A/Guncertain significance
rs45992713:57,602,580A/Gupstream gene variant
rs119253423:57,604,327C/A
rs1918295093:57,609,947G/Adownstream gene variant
rs98524093:57,623,541T/A
rs98736753:57,627,500T/A

Gene information from NCBI Gene. Variant classifications from ClinVar.