PDE7B
phosphodiesterase 7B
Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12209685 | 6:136,228,675 | C/T | intron variant | — |
| rs9402777 | 6:136,242,778 | C/G | — | — |
| rs7774640 | 6:136,265,165 | G/A | intron variant | — |
| rs1017559398 | 6:136,268,606 | G/C | — | uncertain significance |
| rs9402784 | 6:136,350,207 | G/C | — | — |
| rs11154851 | 6:136,368,005 | C/T | intron variant | — |
| rs760181083 | 6:136,429,941 | G/A | — | uncertain significance |
| rs9389370 | 6:136,431,265 | C/G | intron variant | — |
| rs4612174 | 6:136,462,744 | T/G | intron variant | — |
| rs7748159 | 6:136,464,535 | T/G | intron variant | — |
| rs4896199 | 6:136,465,572 | A/C | intron variant | — |
| rs114553138 | 6:136,468,571 | G/A | — | benign |
| rs754900327 | 6:136,470,226 | A/G | — | uncertain significance |
| rs9494457 | 6:136,474,794 | T/A | intron variant | — |
| rs776406458 | 6:136,475,303 | A/C | — | uncertain significance |
| rs35463106 | 6:136,476,782 | G/A | — | benign |
| rs2482682569 | 6:136,476,797 | G/A | — | uncertain significance |
| rs202219333 | 6:136,476,861 | A/G | — | uncertain significance |
| rs193920799 | 6:136,494,965 | C/T | — | uncertain significance |
| rs138283749 | 6:136,494,974 | A/G | — | uncertain significance |
| rs2482718370 | 6:136,494,998 | C/G | — | uncertain significance |
| rs73555079 | 6:136,495,009 | T/C | — | benign |
| rs199957757 | 6:136,500,209 | G/C | — | uncertain significance |
| rs78915419 | 6:136,500,215 | A/G | — | likely benign |
| rs778514785 | 6:136,502,368 | G/T | — | uncertain significance |
| rs556694637 | 6:136,502,405 | T/G | — | uncertain significance |
| rs759491187 | 6:136,502,443 | G/C | — | uncertain significance |
| rs560713 | 6:136,505,036 | A/T | — | — |
| rs2482746257 | 6:136,508,213 | T/C | — | uncertain significance |
| rs766588065 | 6:136,512,911 | G/A | — | uncertain significance |
| rs374387209 | 6:136,512,948 | G/C | — | uncertain significance |
| rs1192428586 | 6:136,512,971 | G/A | — | uncertain significance |
| rs77357372 | 6:136,512,972 | C/G | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.