PGF
placental growth factor
Summary
Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs202127516 | 14:75,409,417 | G/A | — | uncertain significance |
| rs201773217 | 14:75,412,958 | C/T | — | uncertain significance |
| rs142448465 | 14:75,413,104 | G/A | — | uncertain significance |
| rs1392221971 | 14:75,413,106 | A/T | — | uncertain significance |
| rs751046183 | 14:75,415,217 | C/T | — | uncertain significance |
| rs201183034 | 14:75,415,226 | C/T | — | uncertain significance |
| rs371087083 | 14:75,415,240 | G/A | — | uncertain significance |
| rs140548843 | 14:75,415,250 | C/T | — | uncertain significance |
| rs758097328 | 14:75,415,273 | C/A | — | uncertain significance |
| rs2268614 | 14:75,416,000 | C/A | — | — |
| rs1011228776 | 14:75,416,079 | G/A | — | uncertain significance |
| rs372000874 | 14:75,416,194 | C/T | — | likely benign |
| rs371967102 | 14:75,416,214 | G/A | — | uncertain significance |
| rs61759375 | 14:75,416,852 | C/T | regulatory region variant | — |
| rs11542848 | 14:75,422,175 | C/T | regulatory region variant | — |
| rs573241313 | 14:75,422,431 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.