PIAS4
protein inhibitor of activated STAT 4
Summary
Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein localization to chromatin; protein sumoylation; and regulation of primary metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2040012329 | 19:4,013,049 | T/C | — | likely benign |
| rs2144907133 | 19:4,013,082 | G/C | — | uncertain significance |
| rs758152481 | 19:4,013,105 | C/T | — | uncertain significance |
| rs1324632961 | 19:4,013,149 | A/G | — | uncertain significance |
| rs752315957 | 19:4,013,255 | G/C | — | uncertain significance |
| rs144565099 | 19:4,013,262 | C/T | — | likely benign |
| rs111928159 | 19:4,013,263 | G/C | — | uncertain significance |
| rs148740518 | 19:4,013,276 | A/T | — | likely benign |
| rs376431812 | 19:4,013,287 | C/T | — | uncertain significance |
| rs199843551 | 19:4,013,304 | G/A | — | likely benign |
| rs759027208 | 19:4,013,312 | A/C | — | uncertain significance |
| rs147864974 | 19:4,013,328 | G/A | — | likely benign |
| rs552410991 | 19:4,016,163 | C/T | — | — |
| rs147751353 | 19:4,028,553 | G/A | — | likely benign |
| rs1428048271 | 19:4,028,585 | A/G | — | uncertain significance |
| rs141113403 | 19:4,028,593 | G/A | — | uncertain significance |
| rs1002635146 | 19:4,028,605 | A/T | — | uncertain significance |
| rs200365509 | 19:4,028,805 | G/A | — | uncertain significance |
| rs1040676979 | 19:4,028,821 | C/T | — | uncertain significance |
| rs1364169867 | 19:4,028,930 | G/A | — | uncertain significance |
| rs774408856 | 19:4,028,972 | C/T | — | uncertain significance |
| rs755590949 | 19:4,033,100 | A/C | — | uncertain significance |
| rs61729791 | 19:4,033,144 | C/T | — | likely benign |
| rs2512246413 | 19:4,033,170 | C/T | — | uncertain significance |
| rs150771656 | 19:4,033,507 | C/T | — | benign |
| rs201403483 | 19:4,033,587 | G/A | — | likely benign |
| rs139844299 | 19:4,037,393 | C/T | — | likely benign |
| rs200749383 | 19:4,037,394 | G/A | — | uncertain significance |
| rs10417750 | 19:4,037,426 | G/A | — | likely benign |
| rs201898018 | 19:4,037,454 | G/A | — | uncertain significance |
| rs145338811 | 19:4,037,467 | G/A | — | uncertain significance |
| rs771465294 | 19:4,037,487 | G/A | — | uncertain significance |
| rs371055074 | 19:4,037,624 | C/T | — | benign |
| rs371787426 | 19:4,037,664 | G/A | — | uncertain significance |
| rs756402012 | 19:4,037,670 | C/T | — | likely benign |
| rs761339485 | 19:4,037,691 | G/A | — | uncertain significance |
| rs764999661 | 19:4,037,695 | C/T | — | uncertain significance |
| rs140558761 | 19:4,037,723 | G/A | — | likely benign |
| rs775999858 | 19:4,037,782 | A/T | — | uncertain significance |
| rs764177800 | 19:4,037,853 | G/A | — | uncertain significance |
| rs757524630 | 19:4,037,863 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.