PIGR
polymeric immunoglobulin receptor
Summary
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs13190 | 1:207,102,293 | A/T | 3 prime UTR variant | — |
| rs781672177 | 1:207,103,701 | C/T | — | likely benign |
| rs2526269248 | 1:207,105,075 | G/T | — | uncertain significance |
| rs908702 | 1:207,105,641 | C/T | intron variant | — |
| rs779790966 | 1:207,105,831 | C/T | — | uncertain significance |
| rs291102 | 1:207,106,478 | G/A | missense variant | uncertain significance |
| rs1306559599 | 1:207,107,794 | T/G | — | uncertain significance |
| rs749007578 | 1:207,107,815 | T/C | — | uncertain significance |
| rs779064145 | 1:207,107,816 | A/G | — | uncertain significance |
| rs768192779 | 1:207,107,825 | C/T | — | uncertain significance |
| rs369739699 | 1:207,107,870 | C/T | — | uncertain significance |
| rs1299944296 | 1:207,107,909 | C/T | — | uncertain significance |
| rs1228076614 | 1:207,108,903 | C/T | — | uncertain significance |
| rs764503049 | 1:207,108,945 | C/T | — | uncertain significance |
| rs149666963 | 1:207,108,981 | C/T | — | uncertain significance |
| rs774661832 | 1:207,109,028 | C/T | — | uncertain significance |
| rs200375930 | 1:207,109,041 | C/A | — | uncertain significance |
| rs753794076 | 1:207,109,070 | C/T | — | uncertain significance |
| rs35112874 | 1:207,109,071 | T/C | — | likely benign |
| rs2275531 | 1:207,109,116 | C/T | — | benign |
| rs749405589 | 1:207,109,130 | T/G | — | uncertain significance |
| rs774853842 | 1:207,109,133 | A/G | — | uncertain significance |
| rs143383891 | 1:207,109,151 | G/A | — | uncertain significance |
| rs6695632 | 1:207,109,167 | G/A | — | benign |
| rs758782692 | 1:207,110,485 | G/T | — | uncertain significance |
| rs764279486 | 1:207,110,653 | T/A | — | uncertain significance |
| rs761657384 | 1:207,110,680 | A/G | — | uncertain significance |
| rs370527545 | 1:207,110,689 | C/T | — | uncertain significance |
| rs761979881 | 1:207,110,846 | G/T | — | uncertain significance |
| rs761287769 | 1:207,110,851 | G/C | — | uncertain significance |
| rs764862576 | 1:207,110,868 | A/G | — | uncertain significance |
| rs374913362 | 1:207,110,872 | C/T | — | likely benign |
| rs1321496075 | 1:207,111,088 | G/T | — | uncertain significance |
| rs1341487305 | 1:207,112,469 | C/A | — | uncertain significance |
| rs533610297 | 1:207,112,532 | C/T | — | likely benign |
| rs138369670 | 1:207,112,632 | C/T | — | likely benign |
| rs373465414 | 1:207,112,707 | G/A | — | uncertain significance |
| rs762988342 | 1:207,112,736 | G/A | — | uncertain significance |
| rs201367607 | 1:207,112,799 | G/A | — | likely benign |
| rs291091 | 1:207,113,679 | T/C | intron variant | — |
| rs2007272 | 1:207,113,755 | G/A | — | — |
| rs1679959988 | 1:207,113,849 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.