PKN1
protein kinase N1
Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Known Variants74 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1335700690 | 19:14,544,337 | G/A | — | uncertain significance |
| rs377566153 | 19:14,552,000 | G/A | — | uncertain significance |
| rs760608934 | 19:14,552,016 | C/T | — | uncertain significance |
| rs775368223 | 19:14,552,111 | C/T | — | uncertain significance |
| rs933464171 | 19:14,552,180 | C/T | — | uncertain significance |
| rs889292364 | 19:14,552,196 | A/G | — | uncertain significance |
| rs1248525284 | 19:14,552,225 | G/A | — | uncertain significance |
| rs60984983 | 19:14,553,265 | T/C | intron variant | — |
| rs760992040 | 19:14,554,321 | C/T | — | uncertain significance |
| rs2512815621 | 19:14,554,337 | C/A | — | uncertain significance |
| rs372099148 | 19:14,554,339 | G/A | — | uncertain significance |
| rs55814382 | 19:14,554,394 | G/A | — | benign |
| rs750717632 | 19:14,557,241 | C/T | — | uncertain significance |
| rs1350434123 | 19:14,557,312 | A/C | — | uncertain significance |
| rs759249010 | 19:14,557,323 | C/T | — | uncertain significance |
| rs553822326 | 19:14,557,331 | G/A | — | uncertain significance |
| rs978722232 | 19:14,561,133 | G/C | — | uncertain significance |
| rs2512822081 | 19:14,561,150 | G/C | — | uncertain significance |
| rs768512052 | 19:14,561,183 | T/A | — | uncertain significance |
| rs200219286 | 19:14,561,212 | T/C | — | likely benign |
| rs1045385298 | 19:14,561,262 | A/G | — | uncertain significance |
| rs763207797 | 19:14,561,728 | A/C | — | uncertain significance |
| rs761189520 | 19:14,561,856 | C/A | — | uncertain significance |
| rs755902578 | 19:14,561,900 | T/A | — | uncertain significance |
| rs774785867 | 19:14,561,913 | C/T | — | uncertain significance |
| rs560950919 | 19:14,562,662 | T/C | — | uncertain significance |
| rs544790726 | 19:14,562,692 | C/T | — | uncertain significance |
| rs373725067 | 19:14,562,699 | C/G | — | uncertain significance |
| rs200118271 | 19:14,562,712 | A/G | — | likely benign |
| rs199540215 | 19:14,562,742 | C/T | — | uncertain significance |
| rs771298002 | 19:14,562,745 | C/G | — | uncertain significance |
| rs368371989 | 19:14,562,746 | C/A | — | uncertain significance |
| rs746404416 | 19:14,562,757 | C/T | — | uncertain significance |
| rs752546646 | 19:14,562,802 | C/T | — | uncertain significance |
| rs200116263 | 19:14,568,890 | A/T | — | uncertain significance |
| rs1182196571 | 19:14,568,891 | C/T | — | uncertain significance |
| rs2512829725 | 19:14,568,899 | A/G | — | uncertain significance |
| rs762968134 | 19:14,568,915 | A/G | — | likely benign |
| rs201725818 | 19:14,569,047 | C/T | — | uncertain significance |
| rs556203841 | 19:14,569,075 | G/A | — | uncertain significance |
| rs760983411 | 19:14,569,083 | C/T | — | uncertain significance |
| rs201423826 | 19:14,569,194 | C/A | — | benign |
| rs377340991 | 19:14,574,655 | G/A | — | uncertain significance |
| rs200813056 | 19:14,574,718 | A/G | — | uncertain significance |
| rs139622328 | 19:14,574,764 | C/T | — | likely benign |
| rs369267115 | 19:14,574,772 | G/A | — | uncertain significance |
| rs34309238 | 19:14,574,897 | C/A | — | benign |
| rs752968299 | 19:14,574,900 | G/A | — | uncertain significance |
| rs2071503695 | 19:14,578,398 | A/G | — | uncertain significance |
| rs761006104 | 19:14,578,407 | G/C | — | uncertain significance |
| rs372299413 | 19:14,578,566 | C/A | — | uncertain significance |
| rs773303512 | 19:14,578,589 | G/A | — | uncertain significance |
| rs747156720 | 19:14,578,700 | G/A | — | uncertain significance |
| rs760288479 | 19:14,578,727 | G/A | — | uncertain significance |
| rs758102154 | 19:14,578,755 | T/C | — | uncertain significance |
| rs188188103 | 19:14,580,239 | C/T | — | uncertain significance |
| rs774139335 | 19:14,580,269 | C/T | — | uncertain significance |
| rs1262551569 | 19:14,580,320 | C/T | — | uncertain significance |
| rs1298097419 | 19:14,580,565 | T/C | — | uncertain significance |
| rs370875924 | 19:14,580,612 | C/G | — | uncertain significance |
| rs757979289 | 19:14,580,619 | G/A | — | uncertain significance |
| rs1568352901 | 19:14,580,623 | A/G | — | uncertain significance |
| rs200545401 | 19:14,580,993 | G/A | — | uncertain significance |
| rs751733182 | 19:14,581,053 | C/T | — | uncertain significance |
| rs780230893 | 19:14,581,064 | G/A | — | uncertain significance |
| rs767138769 | 19:14,582,393 | A/G | — | uncertain significance |
| rs2512846151 | 19:14,582,430 | C/T | — | uncertain significance |
| rs1456573623 | 19:14,582,482 | C/T | — | likely benign |
| rs2071559657 | 19:14,582,502 | C/A | — | uncertain significance |
| rs747665497 | 19:14,582,522 | C/T | — | uncertain significance |
| rs781467217 | 19:14,582,553 | A/G | — | uncertain significance |
| rs750823948 | 19:14,582,555 | G/A | — | uncertain significance |
| rs780554647 | 19:14,582,558 | G/A | — | uncertain significance |
| rs56119754 | 19:14,582,584 | C/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.