PLA2G15
phospholipase A2 group XV
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs754043665 | 16:68,279,346 | G/T | — | uncertain significance |
| rs142099674 | 16:68,279,421 | C/T | — | uncertain significance |
| rs771226585 | 16:68,279,432 | G/A | — | uncertain significance |
| rs759838921 | 16:68,279,444 | C/G | — | uncertain significance |
| rs1435697637 | 16:68,283,288 | A/G | — | uncertain significance |
| rs2545228708 | 16:68,283,330 | T/G | — | uncertain significance |
| rs17688076 | 16:68,286,427 | C/A | regulatory region variant | — |
| rs1022171279 | 16:68,288,877 | C/T | — | uncertain significance |
| rs369217876 | 16:68,289,235 | C/G | — | uncertain significance |
| rs1326364212 | 16:68,289,277 | G/A | — | uncertain significance |
| rs374139093 | 16:68,289,698 | C/T | — | uncertain significance |
| rs148885583 | 16:68,289,794 | C/T | — | uncertain significance |
| rs762939782 | 16:68,289,806 | G/T | — | uncertain significance |
| rs780364075 | 16:68,293,060 | C/T | — | uncertain significance |
| rs2545242672 | 16:68,293,234 | G/C | — | uncertain significance |
| rs371751482 | 16:68,293,252 | C/T | — | uncertain significance |
| rs149627483 | 16:68,293,286 | T/C | — | uncertain significance |
| rs201206740 | 16:68,293,297 | G/A | — | uncertain significance |
| rs760142209 | 16:68,293,402 | G/A | — | uncertain significance |
| rs753130191 | 16:68,293,450 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.