PLA2G5

phospholipase A2 group V

Summary

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Known Variants99 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs818678	1:20,366,330	T/C	intron variant	—
rs555191407	1:20,377,045	A/G	—	—
rs11573189	1:20,396,126	C/T	—	—
rs525380	1:20,409,374	A/T	—	—
rs2020887	1:20,411,332	T/C	—	benign
rs150035047	1:20,411,338	C/G	—	likely benign
rs372172763	1:20,411,339	C/T	—	uncertain significance
rs2100616205	1:20,411,340	C/T	—	uncertain significance
rs199739019	1:20,411,379	G/A	—	likely benign
rs779836652	1:20,411,383	C/T	—	likely benign
rs1430140432	1:20,412,569	C/T	—	likely benign
rs2016272356	1:20,412,576	G/C	—	uncertain significance
rs762881471	1:20,412,578	G/A	—	uncertain significance
rs2523538873	1:20,412,582	C/T	—	uncertain significance
rs148786946	1:20,412,583	T/C	—	likely benign
rs751296635	1:20,412,593	G/A	—	uncertain significance
rs201974975	1:20,412,596	G/C	—	uncertain significance
rs2016274700	1:20,412,597	G/T	—	uncertain significance
rs781236737	1:20,412,605	G/T	—	uncertain significance
rs2100624025	1:20,412,621	T/C	—	uncertain significance
rs141524733	1:20,412,623	G/A	—	uncertain significance
rs372362269	1:20,412,626	A/G	—	uncertain significance
rs111762734	1:20,412,637	G/T	—	uncertain significance
rs147044650	1:20,412,643	C/T	—	likely benign
rs142480941	1:20,412,645	C/G	—	uncertain significance
rs369115056	1:20,412,658	C/T	—	likely benign
rs1031628964	1:20,412,659	G/A	—	uncertain significance
rs1262533812	1:20,412,667	C/T	—	likely benign
rs387906795	1:20,412,668	G/T	missense variant	uncertain significance
rs2016280180	1:20,412,676	C/T	—	likely benign
rs2100624994	1:20,412,677	T/G	—	uncertain significance
rs11573265	1:20,412,679	C/T	—	benign
rs387906796	1:20,412,680	G/A	missense variant	uncertain significance
rs759206198	1:20,412,688	C/T	—	likely benign
rs1438217452	1:20,412,689	G/A	—	uncertain significance
rs2523541984	1:20,412,690	G/A	—	uncertain significance
rs200954922	1:20,412,692	C/T	stop gained	uncertain significance
rs752798095	1:20,412,693	G/A	—	uncertain significance
rs2523542674	1:20,412,708	A/G	—	uncertain significance
rs757453309	1:20,412,715	C/T	—	likely benign
rs143614555	1:20,412,716	G/A	—	uncertain significance
rs746408116	1:20,412,720	G/A	—	affects
rs2020881	1:20,412,723	G/A	—	benign
rs2016284868	1:20,412,727	T/G	—	likely benign
rs756674976	1:20,412,731	C/T	—	likely benign
rs772897452	1:20,412,732	G/A	—	likely benign
rs1441169003	1:20,416,263	A/C	—	likely benign
rs200026946	1:20,416,276	G/A	—	likely benign
rs2523579463	1:20,416,284	G/A	—	uncertain significance
rs775610294	1:20,416,295	C/T	—	uncertain significance
rs1422616008	1:20,416,308	A/G	—	uncertain significance
rs538789160	1:20,416,313	C/T	—	uncertain significance
rs373547855	1:20,416,314	G/T	—	uncertain significance
rs200355236	1:20,416,321	G/A	—	likely benign
rs2100647768	1:20,416,326	A/G	—	uncertain significance
rs1413403017	1:20,416,341	G/A	—	uncertain significance
rs750501236	1:20,416,345	A/C	—	likely benign
rs1461362985	1:20,416,352	T/A	—	uncertain significance
rs2100648217	1:20,416,355	A/C	—	uncertain significance
rs1287200423	1:20,416,369	G/A	—	likely benign
rs2100648364	1:20,416,372	G/A	—	uncertain significance
rs752087893	1:20,416,376	G/C	—	uncertain significance
rs1011709337	1:20,416,384	C/T	—	likely benign
rs142343582	1:20,416,388	G/A	—	uncertain significance
rs1258443100	1:20,416,394	G/T	—	uncertain significance
rs745353856	1:20,416,401	C/T	—	likely benign
rs771515129	1:20,416,406	C/T	—	likely benign
rs2020889	1:20,416,407	G/A	—	benign
rs2016518132	1:20,417,051	C/G	—	likely benign
rs779714423	1:20,417,052	C/T	—	likely benign
rs2016518632	1:20,417,063	C/T	—	uncertain significance
rs139841773	1:20,417,065	C/T	—	likely benign
rs781327560	1:20,417,066	G/A	—	uncertain significance
rs546917220	1:20,417,069	C/A	—	uncertain significance
rs2016519905	1:20,417,070	C/T	—	uncertain significance
rs752486178	1:20,417,075	T/C	—	uncertain significance
rs571294470	1:20,417,077	C/A	—	uncertain significance
rs139906512	1:20,417,079	A/C	—	uncertain significance
rs149833360	1:20,417,080	T/C	—	conflicting classifications of pathogenicity
rs370385685	1:20,417,089	C/G	—	likely benign
rs1332920433	1:20,417,094	C/T	—	uncertain significance
rs759666214	1:20,417,095	C/G	—	likely benign
rs532418704	1:20,417,102	C/T	—	uncertain significance
rs144012929	1:20,417,110	C/T	—	likely benign
rs183088076	1:20,417,111	G/T	—	uncertain significance
rs766190819	1:20,417,115	A/G	—	uncertain significance
rs754574030	1:20,417,124	A/G	—	uncertain significance
rs755878705	1:20,417,135	C/T	—	uncertain significance
rs140232035	1:20,417,136	G/A	—	uncertain significance
rs1416647199	1:20,417,139	G/A	—	uncertain significance
rs1390456842	1:20,417,150	C/T	—	uncertain significance
rs771124138	1:20,417,151	A/C	—	uncertain significance
rs745908530	1:20,417,157	A/T	—	uncertain significance
rs772162334	1:20,417,158	A/G	—	likely benign
rs2016525641	1:20,417,160	A/G	—	uncertain significance
rs2100653665	1:20,417,168	A/C	—	uncertain significance
rs112000348	1:20,417,170	C/A	—	uncertain significance
rs1212664972	1:20,417,175	T/C	—	uncertain significance
rs1200301817	1:20,417,184	A/G	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.