PLA2R1

phospholipase A2 receptor 1

Summary

This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Known Variants105 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs190463153	2:160,782,600	C/A	intergenic variant	—
rs145231379	2:160,798,299	C/G	—	uncertain significance
rs140273537	2:160,798,517	T/C	intron variant	—
rs202093875	2:160,798,667	A/C	—	uncertain significance
rs546939234	2:160,801,054	C/T	—	—
rs767770232	2:160,801,458	G/A	—	uncertain significance
rs200436825	2:160,801,507	G/A	—	uncertain significance
rs141373544	2:160,801,525	T/C	—	uncertain significance
rs1687295183	2:160,801,542	C/A	—	uncertain significance
rs376484492	2:160,801,584	A/G	—	uncertain significance
rs1291093759	2:160,801,585	T/G	—	uncertain significance
rs149805975	2:160,804,910	T/A	intron variant	—
rs199756577	2:160,806,158	C/T	—	uncertain significance
rs149313808	2:160,806,183	G/A	—	likely benign
rs1048072071	2:160,806,200	C/T	—	uncertain significance
rs910854860	2:160,806,217	G/C	—	uncertain significance
rs1406110220	2:160,806,258	G/A	—	uncertain significance
rs138292225	2:160,806,496	C/G	intron variant	—
rs1278207566	2:160,807,955	T/C	—	uncertain significance
rs749389715	2:160,807,990	G/C	—	uncertain significance
rs3828323	2:160,808,075	C/T	missense variant	benign
rs761375733	2:160,808,077	T/C	—	likely benign
rs112520549	2:160,809,425	A/G	intron variant	—
rs778997231	2:160,811,739	C/T	—	uncertain significance
rs750477651	2:160,811,746	T/C	—	uncertain significance
rs745383387	2:160,812,295	T/C	—	uncertain significance
rs773350950	2:160,812,325	T/A	—	uncertain significance
rs545050830	2:160,813,035	C/T	—	likely benign
rs1560144960	2:160,813,041	A/G	—	uncertain significance
rs765956283	2:160,813,045	C/A	—	likely benign
rs572313740	2:160,813,059	C/G	—	likely benign
rs112080367	2:160,813,089	G/T	—	uncertain significance
rs776201495	2:160,824,136	T/C	—	uncertain significance
rs756189501	2:160,824,177	C/G	—	uncertain significance
rs139465657	2:160,826,668	T/C	—	uncertain significance
rs149692212	2:160,826,674	G/A	—	uncertain significance
rs143007086	2:160,826,713	T/C	—	uncertain significance
rs764478475	2:160,832,682	G/A	—	uncertain significance
rs377065225	2:160,832,709	G/C	—	uncertain significance
rs2715918	2:160,833,188	A/T	—	—
rs144416180	2:160,833,229	C/T	—	uncertain significance
rs570586007	2:160,834,390	G/A	—	—
rs2468389285	2:160,840,446	A/T	—	uncertain significance
rs2468389405	2:160,840,454	T/C	—	uncertain significance
rs751953736	2:160,840,526	C/T	—	uncertain significance
rs575282990	2:160,840,558	C/T	—	uncertain significance
rs570106923	2:160,843,180	C/T	—	—
rs6757188	2:160,843,623	T/C	intron variant	—
rs115349802	2:160,843,747	C/A	—	uncertain significance
rs114280866	2:160,843,748	T/G	—	benign
rs145080815	2:160,843,801	G/A	—	uncertain significance
rs768761126	2:160,843,821	C/A	—	uncertain significance
rs531798955	2:160,843,822	G/A	—	uncertain significance
rs184092428	2:160,845,981	A/C	regulatory region variant	—
rs186102570	2:160,849,220	C/T	intron variant	—
rs181596976	2:160,852,013	A/G	intron variant	—
rs145991174	2:160,852,497	C/A	intron variant	—
rs544467681	2:160,856,940	G/C	—	—
rs151215519	2:160,862,183	T/G	—	likely benign
rs145687288	2:160,862,198	G/A	—	uncertain significance
rs3792174	2:160,862,714	G/A	intron variant	—
rs2667011	2:160,867,059	G/T	—	—
rs73004732	2:160,872,636	G/T	—	—
rs767434437	2:160,873,178	T/C	—	uncertain significance
rs1406553182	2:160,873,200	A/C	—	uncertain significance
rs1489949863	2:160,873,212	C/G	—	uncertain significance
rs55860731	2:160,875,437	C/T	intron variant	—
rs894418369	2:160,876,649	T/C	—	uncertain significance
rs749082735	2:160,876,663	T/C	—	uncertain significance
rs768796788	2:160,876,672	A/G	—	uncertain significance
rs112550092	2:160,876,675	G/A	—	uncertain significance
rs1407074499	2:160,876,697	C/G	—	uncertain significance
rs570992829	2:160,876,753	A/G	—	uncertain significance
rs140155678	2:160,879,360	C/T	—	likely benign
rs190702420	2:160,882,475	T/C	intron variant	—
rs369497962	2:160,884,797	C/T	—	uncertain significance
rs1368929346	2:160,884,816	G/C	—	uncertain significance
rs113724146	2:160,885,415	C/T	—	uncertain significance
rs35771982	2:160,885,418	G/C	missense variant	benign
rs749819959	2:160,885,423	T/G	—	uncertain significance
rs139957604	2:160,885,432	T/C	—	uncertain significance
rs200048543	2:160,885,434	G/A	—	likely benign
rs202185729	2:160,885,441	A/G	—	uncertain significance
rs3749117	2:160,885,442	T/C	missense variant	benign
rs149256089	2:160,889,495	A/G	—	likely benign
rs1243689827	2:160,889,586	C/T	—	uncertain significance
rs766928406	2:160,889,617	T/C	—	likely benign
rs4665141	2:160,890,795	A/C	—	—
rs180964847	2:160,894,756	G/C	intron variant	—
rs759960475	2:160,898,622	C/T	—	uncertain significance
rs768133507	2:160,898,623	G/A	—	uncertain significance
rs139686663	2:160,898,637	T/C	—	uncertain significance
rs147708294	2:160,898,680	C/T	—	uncertain significance
rs145419144	2:160,900,053	G/A	regulatory region variant	—
rs768216919	2:160,901,330	A/G	—	uncertain significance
rs1180067319	2:160,901,339	T/C	—	uncertain significance
rs12327936	2:160,901,353	C/T	—	likely benign
rs4665143	2:160,901,517	A/G	synonymous variant	—
rs2468908946	2:160,901,639	T/A	—	uncertain significance
rs571864714	2:160,905,787	C/T	—	—

Showing 100 of 105 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.