PLCD4
phospholipase C delta 4
Summary
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Known Variants55 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7562973 | 2:219,471,455 | T/C | upstream gene variant | — |
| rs832805 | 2:219,473,737 | T/G | — | — |
| rs832806 | 2:219,473,914 | A/T | intron variant | — |
| rs761632351 | 2:219,480,467 | C/T | — | uncertain significance |
| rs369550268 | 2:219,480,688 | G/T | — | uncertain significance |
| rs1575015608 | 2:219,480,689 | T/C | — | uncertain significance |
| rs200031671 | 2:219,480,733 | C/T | — | likely benign |
| rs373362301 | 2:219,480,755 | C/T | — | uncertain significance |
| rs485765 | 2:219,480,804 | G/A | regulatory region variant | — |
| rs2469527172 | 2:219,483,334 | G/T | — | uncertain significance |
| rs201896370 | 2:219,483,412 | C/T | — | uncertain significance |
| rs2469527599 | 2:219,483,418 | T/G | — | uncertain significance |
| rs2469527832 | 2:219,483,482 | T/C | — | uncertain significance |
| rs773853595 | 2:219,483,497 | T/C | — | uncertain significance |
| rs201000291 | 2:219,483,506 | T/C | — | uncertain significance |
| rs200972923 | 2:219,483,521 | G/A | — | uncertain significance |
| rs200863393 | 2:219,483,526 | G/C | — | uncertain significance |
| rs140194396 | 2:219,483,536 | G/A | — | likely benign |
| rs200222852 | 2:219,486,203 | G/A | — | uncertain significance |
| rs564116874 | 2:219,486,263 | C/T | — | uncertain significance |
| rs754714559 | 2:219,486,264 | G/A | — | uncertain significance |
| rs748468529 | 2:219,487,442 | C/T | — | uncertain significance |
| rs370200930 | 2:219,487,460 | C/A | — | uncertain significance |
| rs1695946733 | 2:219,487,547 | T/C | — | likely benign |
| rs534863670 | 2:219,492,850 | G/T | — | uncertain significance |
| rs765851562 | 2:219,492,862 | C/A | — | uncertain significance |
| rs1696197564 | 2:219,492,896 | A/G | — | uncertain significance |
| rs770723560 | 2:219,494,252 | C/T | — | uncertain significance |
| rs776249194 | 2:219,494,253 | G/A | — | uncertain significance |
| rs200258640 | 2:219,494,261 | C/T | — | uncertain significance |
| rs1252959665 | 2:219,494,267 | G/A | — | uncertain significance |
| rs201051996 | 2:219,495,382 | T/C | — | uncertain significance |
| rs2469563667 | 2:219,495,404 | A/G | — | uncertain significance |
| rs200331219 | 2:219,495,439 | G/T | — | uncertain significance |
| rs375412858 | 2:219,495,443 | G/A | — | likely benign |
| rs200099965 | 2:219,495,446 | A/T | — | uncertain significance |
| rs527387925 | 2:219,495,484 | A/G | — | uncertain significance |
| rs771167345 | 2:219,495,503 | C/T | — | uncertain significance |
| rs61752210 | 2:219,496,909 | A/G | — | likely benign |
| rs751900322 | 2:219,498,439 | T/C | — | uncertain significance |
| rs529917751 | 2:219,498,866 | C/T | — | uncertain significance |
| rs548113968 | 2:219,498,867 | G/A | — | uncertain significance |
| rs200688997 | 2:219,498,943 | G/A | — | uncertain significance |
| rs376838439 | 2:219,499,237 | C/T | — | uncertain significance |
| rs755755440 | 2:219,499,249 | G/A | — | uncertain significance |
| rs939598482 | 2:219,500,547 | T/C | — | uncertain significance |
| rs773336049 | 2:219,500,610 | G/A | — | uncertain significance |
| rs762952324 | 2:219,500,629 | G/A | — | likely benign |
| rs781667898 | 2:219,500,651 | A/G | — | uncertain significance |
| rs767999714 | 2:219,500,996 | G/A | — | uncertain significance |
| rs1313664390 | 2:219,501,052 | G/A | — | likely benign |
| rs775096336 | 2:219,501,065 | G/A | — | uncertain significance |
| rs768240905 | 2:219,501,089 | C/T | — | uncertain significance |
| rs1696750192 | 2:219,501,107 | T/C | — | uncertain significance |
| rs771737211 | 2:219,501,200 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.