PLD4
phospholipase D family member 4
Summary
Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2841277 | 14:105,391,005 | C/A | — | — |
| rs2582532 | 14:105,392,837 | T/C | regulatory region variant | — |
| rs2841280 | 14:105,393,556 | G/A | missense variant | — |
| rs552124233 | 14:105,394,026 | C/T | — | likely benign |
| rs760557206 | 14:105,394,052 | G/A | — | likely benign |
| rs762032870 | 14:105,394,085 | C/G | — | uncertain significance |
| rs2542472777 | 14:105,394,172 | G/A | — | uncertain significance |
| rs756931995 | 14:105,395,219 | T/C | — | uncertain significance |
| rs2542474657 | 14:105,395,246 | G/A | — | uncertain significance |
| rs201959593 | 14:105,395,256 | C/G | — | uncertain significance |
| rs375062151 | 14:105,395,273 | C/T | — | likely benign |
| rs1225570477 | 14:105,395,649 | G/C | — | uncertain significance |
| rs1303907162 | 14:105,395,653 | C/G | — | uncertain significance |
| rs372532453 | 14:105,395,665 | C/A | — | uncertain significance |
| rs1897562782 | 14:105,395,671 | C/A | — | uncertain significance |
| rs1267746080 | 14:105,395,675 | T/C | — | uncertain significance |
| rs750604749 | 14:105,395,704 | G/A | — | uncertain significance |
| rs780085373 | 14:105,395,717 | C/T | — | uncertain significance |
| rs370495774 | 14:105,395,729 | G/A | — | uncertain significance |
| rs746642369 | 14:105,395,740 | G/A | — | uncertain significance |
| rs776003938 | 14:105,395,758 | G/A | — | uncertain significance |
| rs746101864 | 14:105,396,344 | C/T | — | uncertain significance |
| rs778484699 | 14:105,396,345 | G/T | — | uncertain significance |
| rs745477313 | 14:105,396,368 | T/G | — | uncertain significance |
| rs2542476936 | 14:105,396,412 | T/G | — | uncertain significance |
| rs750793265 | 14:105,396,429 | G/A | — | uncertain significance |
| rs1334077652 | 14:105,397,224 | G/A | — | uncertain significance |
| rs988373544 | 14:105,398,107 | C/T | — | uncertain significance |
| rs775973174 | 14:105,398,111 | G/C | — | likely benign |
| rs954534557 | 14:105,398,113 | G/A | — | uncertain significance |
| rs1260131807 | 14:105,398,122 | G/T | — | uncertain significance |
| rs183124456 | 14:105,398,143 | C/T | — | uncertain significance |
| rs2542479420 | 14:105,398,178 | T/A | — | uncertain significance |
| rs188450775 | 14:105,398,195 | C/A | — | uncertain significance |
| rs370109622 | 14:105,398,200 | C/T | — | uncertain significance |
| rs372744359 | 14:105,398,206 | G/C | — | uncertain significance |
| rs200388619 | 14:105,398,220 | C/A | — | uncertain significance |
| rs74316182 | 14:105,398,392 | G/C | — | uncertain significance |
| rs1286190953 | 14:105,398,471 | T/C | — | uncertain significance |
| rs759628235 | 14:105,398,494 | G/A | — | uncertain significance |
| rs759025986 | 14:105,398,511 | C/G | — | uncertain significance |
| rs545456164 | 14:105,398,615 | T/G | — | uncertain significance |
| rs890343032 | 14:105,398,618 | G/A | — | uncertain significance |
| rs747542847 | 14:105,399,144 | G/A | — | uncertain significance |
| rs771234343 | 14:105,399,146 | G/A | — | uncertain significance |
| rs771496344 | 14:105,399,228 | G/C | — | uncertain significance |
| rs1403433449 | 14:105,399,232 | C/G | — | uncertain significance |
| rs763677157 | 14:105,399,270 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.