PLEKHG6
pleckstrin homology and RhoGEF domain containing G6
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in cell junction and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants76 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200609166 | 12:6,421,399 | G/A | — | uncertain significance |
| rs372334122 | 12:6,421,405 | G/A | — | uncertain significance |
| rs762955702 | 12:6,421,459 | T/C | — | uncertain significance |
| rs570197517 | 12:6,421,468 | C/T | — | uncertain significance |
| rs142180572 | 12:6,421,469 | G/A | — | uncertain significance |
| rs567842070 | 12:6,422,328 | C/T | — | likely benign |
| rs1253905309 | 12:6,422,802 | G/A | — | uncertain significance |
| rs767910202 | 12:6,422,804 | C/A | — | uncertain significance |
| rs373302901 | 12:6,422,805 | G/A | — | uncertain significance |
| rs142011399 | 12:6,422,811 | G/A | — | uncertain significance |
| rs376851679 | 12:6,422,818 | G/T | — | uncertain significance |
| rs373567911 | 12:6,422,856 | G/A | — | uncertain significance |
| rs372935564 | 12:6,422,894 | G/A | — | uncertain significance |
| rs200768262 | 12:6,422,906 | G/A | — | uncertain significance |
| rs2497671164 | 12:6,422,940 | C/G | — | uncertain significance |
| rs148340052 | 12:6,422,942 | A/G | — | uncertain significance |
| rs12316586 | 12:6,424,061 | G/A | — | — |
| rs2497679460 | 12:6,424,203 | G/T | — | uncertain significance |
| rs963547032 | 12:6,424,209 | C/A | — | uncertain significance |
| rs1408015919 | 12:6,424,228 | A/G | — | uncertain significance |
| rs201430373 | 12:6,424,235 | G/A | — | uncertain significance |
| rs748117820 | 12:6,424,255 | C/T | — | uncertain significance |
| rs201238168 | 12:6,424,282 | G/A | — | uncertain significance |
| rs368510063 | 12:6,424,732 | G/A | — | uncertain significance |
| rs2497684911 | 12:6,424,798 | C/T | — | uncertain significance |
| rs146053277 | 12:6,425,044 | G/A | — | uncertain significance |
| rs1382188389 | 12:6,425,045 | C/T | — | uncertain significance |
| rs145571054 | 12:6,425,081 | T/C | — | likely benign |
| rs1210256407 | 12:6,425,434 | C/A | — | uncertain significance |
| rs1238558451 | 12:6,425,446 | A/T | — | uncertain significance |
| rs373186526 | 12:6,425,447 | T/A | — | uncertain significance |
| rs935592241 | 12:6,425,451 | C/G | — | uncertain significance |
| rs201044823 | 12:6,425,496 | G/C | — | uncertain significance |
| rs61753337 | 12:6,425,545 | T/C | — | uncertain significance |
| rs1592024942 | 12:6,425,572 | T/C | — | uncertain significance |
| rs2136745899 | 12:6,426,499 | T/C | — | uncertain significance |
| rs373530657 | 12:6,426,553 | A/G | — | uncertain significance |
| rs1947525672 | 12:6,426,846 | A/G | — | uncertain significance |
| rs368643831 | 12:6,427,110 | C/T | — | uncertain significance |
| rs371501774 | 12:6,427,509 | C/G | — | uncertain significance |
| rs201892290 | 12:6,427,518 | G/A | — | uncertain significance |
| rs764740431 | 12:6,427,966 | G/T | — | uncertain significance |
| rs1207351056 | 12:6,428,001 | C/G | — | uncertain significance |
| rs768468004 | 12:6,428,010 | G/C | — | uncertain significance |
| rs773846283 | 12:6,428,035 | G/A | — | uncertain significance |
| rs1245222167 | 12:6,428,167 | C/A | — | uncertain significance |
| rs10849441 | 12:6,435,571 | A/G | regulatory region variant | — |
| rs375928822 | 12:6,435,597 | G/A | — | likely benign |
| rs760785966 | 12:6,435,643 | A/T | — | uncertain significance |
| rs1379592267 | 12:6,435,655 | T/C | — | uncertain significance |
| rs746216505 | 12:6,435,699 | A/C | — | uncertain significance |
| rs762128718 | 12:6,435,730 | C/T | — | uncertain significance |
| rs770134208 | 12:6,435,734 | G/C | — | uncertain significance |
| rs756798537 | 12:6,436,448 | C/A | — | uncertain significance |
| rs141304328 | 12:6,436,520 | G/A | — | uncertain significance |
| rs1301347530 | 12:6,436,545 | C/T | — | uncertain significance |
| rs144670321 | 12:6,436,569 | G/A | — | uncertain significance |
| rs71584817 | 12:6,436,574 | C/T | — | likely benign |
| rs2497764957 | 12:6,436,584 | C/A | — | uncertain significance |
| rs761130148 | 12:6,436,590 | G/C | — | uncertain significance |
| rs1043225952 | 12:6,436,601 | C/T | — | uncertain significance |
| rs1947902176 | 12:6,436,646 | C/T | — | uncertain significance |
| rs140456993 | 12:6,436,658 | G/A | — | likely benign |
| rs2497767547 | 12:6,436,688 | C/T | — | uncertain significance |
| rs765760533 | 12:6,436,775 | G/A | — | uncertain significance |
| rs1947913845 | 12:6,436,847 | C/T | — | uncertain significance |
| rs763403215 | 12:6,436,862 | G/A | — | uncertain significance |
| rs1158895472 | 12:6,436,938 | T/C | — | uncertain significance |
| rs146608432 | 12:6,436,940 | C/T | — | uncertain significance |
| rs772226256 | 12:6,436,976 | C/T | — | uncertain significance |
| rs2497772068 | 12:6,436,991 | A/G | — | uncertain significance |
| rs373498072 | 12:6,437,021 | C/T | — | uncertain significance |
| rs376541135 | 12:6,437,036 | C/T | — | uncertain significance |
| rs1325375189 | 12:6,437,052 | C/T | — | uncertain significance |
| rs374620511 | 12:6,437,070 | G/A | — | uncertain significance |
| rs200557772 | 12:6,437,088 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.