PLEKHO1
pleckstrin homology domain containing O1
Summary
Predicted to be involved in regulation of myoblast fusion. Predicted to act upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in muscle cell projection membrane and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs782043145 | 1:150,122,466 | T/C | — | uncertain significance |
| rs74124329 | 1:150,123,098 | G/T | — | benign |
| rs2526527017 | 1:150,123,174 | G/A | — | uncertain significance |
| rs781863904 | 1:150,128,275 | A/T | — | uncertain significance |
| rs1553820368 | 1:150,128,371 | C/T | — | uncertain significance |
| rs148544623 | 1:150,128,378 | A/G | — | uncertain significance |
| rs782239583 | 1:150,128,392 | G/A | — | uncertain significance |
| rs782002585 | 1:150,129,113 | C/G | — | uncertain significance |
| rs868975557 | 1:150,129,195 | C/T | — | uncertain significance |
| rs146414526 | 1:150,129,196 | G/A | — | uncertain significance |
| rs74124334 | 1:150,129,443 | C/T | regulatory region variant | — |
| rs199760053 | 1:150,131,155 | C/T | — | uncertain significance |
| rs139280863 | 1:150,131,173 | C/T | — | uncertain significance |
| rs782805199 | 1:150,131,195 | G/A | — | uncertain significance |
| rs781824875 | 1:150,131,228 | C/T | — | uncertain significance |
| rs1553821317 | 1:150,131,267 | A/G | — | uncertain significance |
| rs782134113 | 1:150,131,279 | C/T | — | uncertain significance |
| rs115889989 | 1:150,131,290 | C/T | — | uncertain significance |
| rs2526565514 | 1:150,131,300 | C/G | — | uncertain significance |
| rs2526566004 | 1:150,131,337 | T/A | — | likely benign |
| rs141174945 | 1:150,131,353 | C/T | — | benign |
| rs782766870 | 1:150,131,361 | T/A | — | likely benign |
| rs141878048 | 1:150,131,393 | C/T | — | uncertain significance |
| rs782485298 | 1:150,131,396 | G/A | — | uncertain significance |
| rs79398675 | 1:150,131,410 | A/C | — | uncertain significance |
| rs2526567914 | 1:150,131,525 | C/T | — | uncertain significance |
| rs147586035 | 1:150,131,630 | A/G | — | uncertain significance |
| rs781850409 | 1:150,131,664 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.