PLG

plasminogen

Summary

The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]

Known Variants376 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs4252052	6:161,122,221	C/T	upstream gene variant	—
rs4252053	6:161,122,274	A/G	upstream gene variant	—
rs4063598	6:161,122,931	G/A	—	benign
rs1830521	6:161,123,158	G/T	—	benign
rs1950562	6:161,123,185	T/C	—	benign
rs4252060	6:161,123,302	G/A	—	benign
rs4252061	6:161,123,348	G/A	—	likely benign
rs1339857891	6:161,123,352	G/A	—	uncertain significance
rs764121149	6:161,123,353	T/C	—	uncertain significance
rs371469289	6:161,123,372	A/G	—	likely benign
rs1191830134	6:161,123,376	C/G	—	uncertain significance
rs780341937	6:161,123,392	C/G	—	likely benign
rs749659246	6:161,123,396	G/A	—	likely benign
rs2484296946	6:161,123,400	T/A	—	likely benign
rs566392051	6:161,123,403	T/C	—	likely benign
rs2314851	6:161,123,413	G/T	—	benign
rs4252185	6:161,123,451	T/C	—	benign
rs534452768	6:161,125,335	T/C	—	—
rs4252066	6:161,127,125	G/A	—	benign
rs139837651	6:161,127,423	G/A	—	benign
rs1777524086	6:161,127,435	C/G	—	uncertain significance
rs755657852	6:161,127,439	G/T	—	uncertain significance
rs753547888	6:161,127,445	G/C	—	uncertain significance
rs776968748	6:161,127,473	C/A	—	likely benign
rs1051644668	6:161,127,475	A/C	—	uncertain significance
rs73015965	6:161,127,501	A/G	missense variant	pathogenic
rs138353396	6:161,127,504	A/C	—	uncertain significance
rs1262077328	6:161,127,507	C/A	—	uncertain significance
rs781448572	6:161,127,549	G/A	—	uncertain significance
rs2484311027	6:161,127,553	A/G	—	uncertain significance
rs746034511	6:161,127,554	G/A	—	likely benign
rs144100362	6:161,127,557	C/T	—	likely benign
rs4252070	6:161,127,558	G/A	—	benign
rs886042477	6:161,127,575	G/T	—	pathogenic
rs117192504	6:161,127,578	T/C	—	benign
rs1003532006	6:161,127,587	T/A	—	likely benign
rs369616302	6:161,127,588	C/A	—	conflicting classifications of pathogenicity
rs192461252	6:161,127,589	G/A	—	likely benign
rs1260206377	6:161,127,590	T/C	—	likely benign
rs4252075	6:161,128,617	A/G	—	benign
rs371083243	6:161,128,723	G/A	—	likely benign
rs770768604	6:161,128,772	A/T	—	uncertain significance
rs781084043	6:161,128,775	G/A	—	uncertain significance
rs189824042	6:161,128,810	G/A	—	uncertain significance
rs143079629	6:161,128,812	G/A	—	uncertain significance
rs750930821	6:161,128,835	A/C	—	uncertain significance
rs2484315324	6:161,128,855	C/T	—	likely benign
rs552232588	6:161,128,856	C/T	—	likely benign
rs756816534	6:161,128,857	T/G	—	likely benign
rs783143	6:161,128,887	G/A	—	benign
rs4252076	6:161,128,922	A/G	—	benign
rs1740420	6:161,128,945	T/C	—	benign
rs1652508	6:161,128,947	G/A	—	benign
rs140464935	6:161,128,967	G/A	—	benign
rs59614420	6:161,129,013	G/A	—	benign
rs4252078	6:161,131,818	C/T	—	benign
rs773735177	6:161,132,095	G/A	—	uncertain significance
rs2484324739	6:161,132,107	A/G	—	likely pathogenic
rs750185991	6:161,132,129	A/G	—	conflicting classifications of pathogenicity
rs141284301	6:161,132,132	G/T	—	uncertain significance
rs778599053	6:161,132,133	G/C	—	uncertain significance
rs747756137	6:161,132,134	G/A	—	likely benign
rs4757	6:161,132,146	C/T	—	benign
rs139357983	6:161,132,157	C/T	—	uncertain significance
rs776970597	6:161,132,158	G/T	—	likely benign
rs377275189	6:161,132,173	A/T	—	uncertain significance
rs370856655	6:161,132,184	C/T	—	uncertain significance
rs4252186	6:161,132,215	C/A	—	uncertain significance
rs199833895	6:161,132,219	C/T	—	uncertain significance
rs544452740	6:161,132,221	T/C	—	likely benign
rs4252082	6:161,132,417	T/G	—	benign
rs4252091	6:161,133,559	A/G	intron variant	—
rs4252093	6:161,133,685	A/G	—	benign
rs2484330286	6:161,134,000	C/T	—	likely benign
rs765261987	6:161,134,014	C/T	—	likely benign
rs2484330340	6:161,134,023	C/A	—	uncertain significance
rs374989402	6:161,134,027	T/C	—	likely benign
rs1202259118	6:161,134,032	C/T	—	uncertain significance
rs777371711	6:161,134,036	C/A	—	uncertain significance
rs751122910	6:161,134,037	C/T	—	uncertain significance
rs756944864	6:161,134,038	C/G	—	uncertain significance
rs781343369	6:161,134,045	G/T	—	uncertain significance
rs2484330483	6:161,134,057	G/T	—	uncertain significance
rs144153702	6:161,134,069	G/A	—	likely benign
rs756533019	6:161,134,076	G/A	—	uncertain significance
rs146415258	6:161,134,078	C/A	—	uncertain significance
rs372617319	6:161,134,081	C/T	—	likely benign
rs201792453	6:161,134,086	C/T	—	uncertain significance
rs555922023	6:161,134,087	G/C	—	likely benign
rs575946180	6:161,134,093	G/T	—	likely benign
rs1235641340	6:161,134,095	C/T	—	uncertain significance
rs139828885	6:161,134,103	T/C	—	uncertain significance
rs143256245	6:161,134,115	C/A	—	uncertain significance
rs145535174	6:161,134,124	A/G	—	uncertain significance
rs2484330748	6:161,134,127	T/C	—	uncertain significance
rs2484330750	6:161,134,130	G/A	—	uncertain significance
rs558599800	6:161,134,138	C/T	—	likely benign
rs1207671489	6:161,134,147	T/G	—	likely benign
rs369353385	6:161,134,148	G/A	—	uncertain significance
rs2484330912	6:161,134,157	G/C	—	uncertain significance

Showing 100 of 376 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.