PLPP4
phospholipid phosphatase 4
Summary
Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Predicted to be active in membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants14 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1267407483 | 10:122,273,487 | A/C | — | uncertain significance |
| rs118048115 | 10:122,279,476 | A/T | intron variant | — |
| rs777638028 | 10:122,280,493 | G/A | — | uncertain significance |
| rs1194419834 | 10:122,280,506 | G/A | — | uncertain significance |
| rs768298628 | 10:122,280,559 | G/A | — | uncertain significance |
| rs201679766 | 10:122,280,578 | G/A | — | uncertain significance |
| rs7069705 | 10:122,295,273 | C/T | intron variant | — |
| rs374443612 | 10:122,334,693 | C/T | — | uncertain significance |
| rs771277249 | 10:122,334,698 | C/G | — | uncertain significance |
| rs770040474 | 10:122,334,705 | G/C | — | uncertain significance |
| rs538498909 | 10:122,334,732 | C/T | — | uncertain significance |
| rs181897300 | 10:122,336,602 | A/G | intron variant | — |
| rs761248708 | 10:122,348,902 | A/G | — | uncertain significance |
| rs1047369 | 10:122,348,969 | T/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.