PLXNA1
plexin A1
Summary
Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; nervous system development; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection extension; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants516 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7649075 | 3:126,706,800 | C/G | upstream gene variant | — |
| rs576960383 | 3:126,707,441 | C/A | — | uncertain significance |
| rs72957093 | 3:126,707,450 | C/T | — | benign |
| rs552827234 | 3:126,707,451 | G/T | — | likely benign |
| rs574438166 | 3:126,707,452 | C/T | — | likely benign |
| rs760922596 | 3:126,707,453 | G/A | — | uncertain significance |
| rs375859367 | 3:126,707,456 | G/T | — | likely benign |
| rs373455804 | 3:126,707,469 | C/T | — | likely benign |
| rs563093512 | 3:126,707,485 | T/C | — | likely benign |
| rs1023386198 | 3:126,707,501 | C/T | — | likely benign |
| rs375921132 | 3:126,707,502 | G/A | — | likely benign |
| rs779320185 | 3:126,707,522 | G/C | — | uncertain significance |
| rs747274300 | 3:126,707,539 | G/A | — | uncertain significance |
| rs140411089 | 3:126,707,551 | C/A | — | uncertain significance |
| rs372314843 | 3:126,707,554 | C/G | — | benign |
| rs528513486 | 3:126,707,555 | C/A | — | uncertain significance |
| rs1291537634 | 3:126,707,556 | C/T | — | likely benign |
| rs370823812 | 3:126,707,560 | C/T | — | uncertain significance |
| rs778047319 | 3:126,707,570 | C/T | — | uncertain significance |
| rs144129798 | 3:126,707,571 | G/A | — | likely benign |
| rs146428172 | 3:126,707,573 | C/A | — | uncertain significance |
| rs764260543 | 3:126,707,578 | G/A | — | uncertain significance |
| rs369333170 | 3:126,707,604 | G/A | — | likely benign |
| rs373400719 | 3:126,707,619 | C/T | — | likely benign |
| rs1196769968 | 3:126,707,620 | G/A | — | uncertain significance |
| rs760362109 | 3:126,707,623 | G/T | — | uncertain significance |
| rs569514108 | 3:126,707,634 | C/T | — | likely benign |
| rs2078974408 | 3:126,707,645 | G/A | — | uncertain significance |
| rs540036317 | 3:126,707,661 | G/A | — | likely benign |
| rs2472503219 | 3:126,707,664 | G/C | — | likely benign |
| rs749105753 | 3:126,707,667 | C/G | — | uncertain significance |
| rs748023149 | 3:126,707,673 | A/G | — | likely benign |
| rs936637159 | 3:126,707,694 | G/A | — | likely benign |
| rs373197049 | 3:126,707,727 | G/A | — | likely benign |
| rs375875486 | 3:126,707,730 | G/A | — | likely benign |
| rs1347349953 | 3:126,707,737 | G/A | — | uncertain significance |
| rs1197499434 | 3:126,707,750 | C/T | — | uncertain significance |
| rs143094550 | 3:126,707,755 | G/A | — | likely benign |
| rs151164953 | 3:126,707,765 | G/A | — | uncertain significance |
| rs768094739 | 3:126,707,780 | A/G | — | uncertain significance |
| rs2107620082 | 3:126,707,792 | T/C | — | likely pathogenic |
| rs141064930 | 3:126,707,805 | C/T | — | benign |
| rs367975178 | 3:126,707,806 | G/A | — | uncertain significance |
| rs1193792071 | 3:126,707,822 | C/T | — | uncertain significance |
| rs755191074 | 3:126,707,832 | C/T | — | likely benign |
| rs777769843 | 3:126,707,856 | C/T | — | likely benign |
| rs2078975765 | 3:126,707,869 | G/A | — | uncertain significance |
| rs376171292 | 3:126,707,883 | G/A | — | likely benign |
| rs775237610 | 3:126,707,922 | C/T | — | likely benign |
| rs370552319 | 3:126,707,923 | G/A | — | uncertain significance |
| rs2078976011 | 3:126,707,932 | G/A | — | uncertain significance |
| rs150244244 | 3:126,707,945 | C/T | — | uncertain significance |
| rs978150723 | 3:126,707,956 | A/T | — | uncertain significance |
| rs925369377 | 3:126,707,960 | C/T | — | uncertain significance |
| rs766513199 | 3:126,707,961 | C/T | — | likely benign |
| rs564057481 | 3:126,707,962 | G/A | — | uncertain significance |
| rs765473425 | 3:126,707,970 | G/A | — | likely benign |
| rs200092438 | 3:126,707,978 | G/A | — | uncertain significance |
| rs1200023384 | 3:126,707,985 | C/T | — | likely benign |
| rs367854425 | 3:126,707,994 | C/T | — | likely benign |
| rs143323039 | 3:126,708,009 | C/T | — | likely benign |
| rs371691614 | 3:126,708,018 | G/T | — | uncertain significance |
| rs147104661 | 3:126,708,050 | G/A | — | uncertain significance |
| rs761287603 | 3:126,708,053 | T/G | — | uncertain significance |
| rs939000109 | 3:126,708,055 | A/T | — | uncertain significance |
| rs149556400 | 3:126,708,063 | C/T | — | likely benign |
| rs1187112713 | 3:126,708,072 | T/A | — | uncertain significance |
| rs753021262 | 3:126,708,075 | C/T | — | likely benign |
| rs200971189 | 3:126,708,076 | G/A | — | uncertain significance |
| rs368950629 | 3:126,708,084 | C/T | — | likely benign |
| rs529263070 | 3:126,708,085 | G/A | — | uncertain significance |
| rs1302949261 | 3:126,708,096 | C/T | — | likely benign |
| rs369896128 | 3:126,708,141 | G/A | — | likely benign |
| rs1439327711 | 3:126,708,155 | C/T | — | uncertain significance |
| rs2107620298 | 3:126,708,208 | T/C | — | uncertain significance |
| rs201617251 | 3:126,708,215 | C/T | — | uncertain significance |
| rs781531297 | 3:126,708,222 | G/A | — | likely benign |
| rs1394609958 | 3:126,708,245 | C/T | — | uncertain significance |
| rs200107075 | 3:126,708,252 | C/T | — | likely benign |
| rs773111448 | 3:126,708,253 | G/A | — | uncertain significance |
| rs369940054 | 3:126,708,256 | G/A | — | uncertain significance |
| rs141445214 | 3:126,708,267 | C/T | — | likely benign |
| rs758015230 | 3:126,708,273 | G/A | — | likely benign |
| rs146246704 | 3:126,708,282 | C/A | — | likely benign |
| rs756459337 | 3:126,708,283 | G/A | — | uncertain significance |
| rs139269120 | 3:126,708,300 | C/T | — | likely benign |
| rs144161897 | 3:126,708,318 | G/A | — | likely benign |
| rs146511348 | 3:126,708,321 | C/T | — | likely benign |
| rs372794860 | 3:126,708,342 | C/T | — | benign |
| rs139482007 | 3:126,708,351 | G/A | — | likely benign |
| rs6809502 | 3:126,708,375 | G/A | — | benign |
| rs374901417 | 3:126,708,391 | C/A | — | likely benign |
| rs377693045 | 3:126,708,392 | G/A | — | conflicting classifications of pathogenicity |
| rs762452723 | 3:126,708,406 | C/T | — | likely benign |
| rs376338024 | 3:126,708,408 | G/T | — | likely benign |
| rs765878123 | 3:126,708,441 | C/T | — | likely benign |
| rs6773789 | 3:126,708,453 | T/C | — | benign |
| rs61746811 | 3:126,708,459 | C/T | — | benign |
| rs2078979874 | 3:126,708,463 | C/G | — | uncertain significance |
| rs371310828 | 3:126,708,479 | G/C | — | uncertain significance |
Showing 100 of 516 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.