POLQ

DNA polymerase theta

Summary

Enables several functions, including catalytic activity, acting on DNA; identical protein binding activity; and magnesium ion binding activity. Involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. Is active in mitochondrial nucleoid; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants2,665 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1302554008	3:121,151,154	C/G	—	likely benign
rs1377392438	3:121,151,156	C/T	—	uncertain significance
rs2546744272	3:121,151,160	A/G	—	likely benign
rs2546744275	3:121,151,163	G/A	—	likely benign
rs2047500790	3:121,151,165	C/A	—	uncertain significance
rs2546744288	3:121,151,176	C/G	—	uncertain significance
rs2546744289	3:121,151,177	C/T	—	uncertain significance
rs2047500937	3:121,151,180	A/C	—	uncertain significance
rs200895587	3:121,151,181	G/A	—	likely benign
rs368379916	3:121,151,187	G/A	—	likely benign
rs2546744308	3:121,151,190	T/C	—	uncertain significance
rs2047501200	3:121,151,192	T/C	—	uncertain significance
rs746660883	3:121,151,194	T/C	—	uncertain significance
rs2047501344	3:121,151,197	A/T	—	uncertain significance
rs770769921	3:121,151,207	T/G	—	uncertain significance
rs2546744341	3:121,151,211	T/C	—	likely benign
rs2546744346	3:121,151,215	A/C	—	uncertain significance
rs2546744353	3:121,151,220	C/T	—	likely benign
rs2546744357	3:121,151,221	A/T	—	uncertain significance
rs2108770674	3:121,151,227	A/G	—	uncertain significance
rs2546744376	3:121,151,229	A/G	—	likely benign
rs2546744378	3:121,151,231	C/A	—	uncertain significance
rs2546744380	3:121,151,232	A/G	—	likely benign
rs2047501727	3:121,151,239	A/G	—	uncertain significance
rs142930622	3:121,151,240	T/C	—	uncertain significance
rs150701139	3:121,151,243	C/T	—	uncertain significance
rs2047501939	3:121,151,247	C/A	—	uncertain significance
rs2546744397	3:121,151,248	T/C	—	uncertain significance
rs2546744399	3:121,151,250	G/C	—	likely benign
rs2546744401	3:121,151,251	A/G	—	uncertain significance
rs995367527	3:121,151,252	C/T	—	uncertain significance
rs372403254	3:121,151,262	T/C	—	likely benign
rs3772119	3:121,151,264	C/T	—	uncertain significance
rs2546744777	3:121,151,767	G/C	—	uncertain significance
rs768706265	3:121,151,770	C/A	—	uncertain significance
rs376359599	3:121,151,771	A/C	—	likely benign
rs1322820385	3:121,151,773	C/T	—	uncertain significance
rs1281287076	3:121,151,774	A/G	—	likely benign
rs2047508976	3:121,151,777	T/A	—	uncertain significance
rs368813941	3:121,151,782	C/G	—	uncertain significance
rs2546744828	3:121,151,783	T/G	—	likely benign
rs2306211	3:121,151,784	A/G	—	benign
rs1409279410	3:121,151,785	C/T	—	uncertain significance
rs2546744840	3:121,151,792	A/G	—	likely benign
rs765248766	3:121,151,794	A/G	—	uncertain significance
rs2047509688	3:121,151,795	T/C	—	likely benign
rs2546744847	3:121,151,796	A/G	—	uncertain significance
rs2546744849	3:121,151,797	G/T	—	uncertain significance
rs978988875	3:121,151,798	G/A	—	likely benign
rs1442530873	3:121,151,800	G/T	—	uncertain significance
rs1414245609	3:121,151,802	T/C	—	uncertain significance
rs1173368512	3:121,151,806	C/T	—	uncertain significance
rs767757235	3:121,151,807	A/G	—	likely benign
rs3218634	3:121,151,812	G/C	missense variant	benign
rs756534857	3:121,151,813	T/G	—	uncertain significance
rs1184837633	3:121,151,814	T/G	—	uncertain significance
rs1191548844	3:121,151,822	G/A	—	likely benign
rs2546744881	3:121,151,824	A/C	—	uncertain significance
rs1180039682	3:121,151,825	G/A	—	likely benign
rs752078167	3:121,151,829	C/G	—	uncertain significance
rs2108770967	3:121,151,832	C/T	—	uncertain significance
rs144679936	3:121,151,836	T/C	—	uncertain significance
rs1456631513	3:121,151,839	T/C	—	likely benign
rs2047510771	3:121,151,842	G/A	—	uncertain significance
rs943784048	3:121,151,844	C/T	—	uncertain significance
rs750113313	3:121,151,849	C/T	—	uncertain significance
rs1472714024	3:121,151,850	A/G	—	uncertain significance
rs755724546	3:121,151,851	T/C	—	uncertain significance
rs779569823	3:121,151,852	C/T	—	likely benign
rs748887344	3:121,151,855	T/G	—	uncertain significance
rs1399030575	3:121,151,858	C/A	—	likely benign
rs2546744919	3:121,151,860	G/A	—	likely benign
rs2546744924	3:121,151,862	T/C	—	uncertain significance
rs1426603372	3:121,151,863	T/C	—	uncertain significance
rs778863249	3:121,151,864	T/C	—	likely benign
rs1318479193	3:121,151,865	C/T	—	uncertain significance
rs200303341	3:121,151,871	C/T	—	uncertain significance
rs2546744941	3:121,151,874	G/A	—	likely benign
rs2546744943	3:121,151,875	A/G	—	uncertain significance
rs199909034	3:121,151,879	T/C	—	likely benign
rs6800901	3:121,154,193	C/T	intron variant	—
rs1381057	3:121,154,974	T/C	—	benign
rs775811252	3:121,154,976	G/A	—	likely benign
rs2546747156	3:121,154,979	A/T	—	uncertain significance
rs2546747160	3:121,154,982	T/C	—	likely benign
rs2047541991	3:121,154,991	A/G	—	likely benign
rs145493365	3:121,154,992	C/A	—	uncertain significance
rs2546747176	3:121,154,993	C/G	—	uncertain significance
rs761979819	3:121,154,998	C/T	—	uncertain significance
rs147692745	3:121,154,999	G/C	—	uncertain significance
rs773572077	3:121,155,001	T/C	—	uncertain significance
rs1288407680	3:121,155,006	A/G	—	likely benign
rs2546747217	3:121,155,009	G/A	—	likely benign
rs2546747220	3:121,155,013	T/G	—	uncertain significance
rs2546747229	3:121,155,020	T/G	—	uncertain significance
rs2546747231	3:121,155,021	T/C	—	likely benign
rs2546747236	3:121,155,024	G/A	—	likely benign
rs2546747239	3:121,155,026	G/T	—	uncertain significance
rs140535924	3:121,155,027	G/C	—	uncertain significance
rs1383955675	3:121,155,029	A/C	—	uncertain significance

Showing 100 of 2,665 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.