PPP1CB

protein phosphatase 1 catalytic subunit beta

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Known Variants220 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs149468963	2:28,974,291	T/C	—	likely benign
rs115890199	2:28,974,338	C/G	—	likely benign
rs7598876	2:28,974,466	T/C	—	benign
rs147139861	2:28,974,530	A/C	—	likely benign
rs115360250	2:28,974,591	C/G	—	benign
rs556879162	2:28,974,623	C/G	—	benign
rs766627964	2:28,974,666	G/A	—	benign
rs377326423	2:28,974,683	G/A	—	benign
rs530957503	2:28,974,897	C/T	—	likely benign
rs200924573	2:28,974,968	G/A	—	likely benign
rs2465670957	2:28,974,990	G/C	—	uncertain significance
rs1305465866	2:28,974,995	C/T	—	uncertain significance
rs367543172	2:28,974,996	G/A	—	likely benign
rs367543173	2:28,975,000	G/A	—	not provided
rs1456860668	2:28,975,002	G/A	—	likely benign
rs1158082133	2:28,975,003	G/C	—	uncertain significance
rs2465671035	2:28,975,006	C/G	—	uncertain significance
rs2465671043	2:28,975,010	A/C	—	uncertain significance
rs1407095225	2:28,975,011	C/A	—	uncertain significance
rs141050112	2:28,975,017	C/T	—	benign
rs1404169743	2:28,975,020	C/T	—	likely benign
rs960710587	2:28,975,021	C/G	—	uncertain significance
rs1300900310	2:28,975,023	C/T	—	likely benign
rs1666312111	2:28,975,028	C/T	—	uncertain significance
rs370579366	2:28,975,029	C/T	—	likely benign
rs1192574840	2:28,975,032	G/C	—	likely benign
rs1055291526	2:28,975,033	C/T	—	likely benign
rs1370587261	2:28,975,036	C/T	—	likely benign
rs2465671269	2:28,975,045	G/A	—	uncertain significance
rs1270847152	2:28,975,050	C/T	—	likely benign
rs1189354406	2:28,975,052	C/T	—	likely benign
rs1488117478	2:28,975,053	G/C	—	likely benign
rs1666313854	2:28,975,056	T/G	—	likely benign
rs113766757	2:28,975,057	G/T	—	likely benign
rs1666314121	2:28,975,059	C/G	—	likely benign
rs1262532368	2:28,975,061	G/A	—	likely benign
rs2276547	2:28,975,107	G/C	—	benign
rs114288521	2:28,975,262	C/T	—	likely benign
rs541660867	2:28,975,324	G/A	—	likely benign
rs4665434	2:28,976,403	A/G	regulatory region variant	—
rs6547872	2:28,978,074	C/T	intron variant	—
rs749325712	2:28,999,698	T/G	—	likely benign
rs2465724260	2:28,999,699	T/G	—	likely benign
rs770933758	2:28,999,700	T/A	—	likely benign
rs376535535	2:28,999,701	A/G	—	likely benign
rs1317648463	2:28,999,706	T/C	—	likely benign
rs1360665709	2:28,999,707	C/T	—	likely benign
rs368197884	2:28,999,708	G/T	—	likely benign
rs767756340	2:28,999,712	G/T	—	likely benign
rs1667055525	2:28,999,727	T/C	—	likely benign
rs2465724340	2:28,999,735	G/T	—	uncertain significance
rs2465724347	2:28,999,738	A/G	—	uncertain significance
rs1667055747	2:28,999,743	G/A	—	uncertain significance
rs2465724390	2:28,999,757	A/G	—	likely benign
rs760562458	2:28,999,758	G/A	—	uncertain significance
rs2148048861	2:28,999,759	C/T	—	uncertain significance
rs2148048864	2:28,999,766	T/A	—	uncertain significance
rs1667056053	2:28,999,768	G/A	—	conflicting classifications of pathogenicity
rs367543174	2:28,999,778	T/C	—	likely benign
rs1166955973	2:28,999,787	T/A	—	likely benign
rs1416950365	2:28,999,790	G/A	—	likely benign
rs2465724546	2:28,999,800	C/T	—	uncertain significance
rs2465724556	2:28,999,803	A/G	—	uncertain significance
rs2148048888	2:28,999,805	C/A	—	uncertain significance
rs2465724561	2:28,999,806	C/G	—	uncertain significance
rs2465724563	2:28,999,809	C/A	—	uncertain significance
rs886037952	2:28,999,810	C/G	missense variant	pathogenic
rs2465724571	2:28,999,817	T/G	—	likely benign
rs1331465727	2:28,999,818	T/C	—	likely benign
rs2465724579	2:28,999,820	G/A	—	likely benign
rs1114167429	2:28,999,830	G/C	missense variant	pathogenic
rs749986410	2:28,999,835	G/A	—	likely benign
rs758093612	2:28,999,841	A/G	—	likely benign
rs1339330369	2:28,999,844	T/C	—	likely benign
rs201593503	2:28,999,852	T/C	—	uncertain significance
rs1667057404	2:28,999,861	G/A	—	likely benign
rs756571902	2:28,999,863	A/G	—	likely benign
rs749740559	2:28,999,868	T/A	—	likely benign
rs149532888	2:28,999,943	G/A	—	likely benign
rs116183638	2:29,000,178	A/C	—	likely benign
rs115804757	2:29,001,515	T/C	—	likely benign
rs114559491	2:29,001,531	T/C	—	likely benign
rs754229094	2:29,001,657	G/T	—	likely benign
rs757727146	2:29,001,660	T/C	—	likely benign
rs779441599	2:29,001,661	C/T	—	likely benign
rs528774950	2:29,001,665	C/G	—	likely benign
rs1667090919	2:29,001,681	T/C	—	uncertain significance
rs991143814	2:29,001,685	T/C	—	likely benign
rs1553310737	2:29,001,687	G/C	—	uncertain significance
rs780001620	2:29,001,688	A/G	—	likely benign
rs1128416	2:29,001,691	A/G	—	benign
rs1667091334	2:29,001,695	A/T	—	uncertain significance
rs768794278	2:29,001,697	A/C	—	likely benign
rs2465727994	2:29,001,704	C/T	—	likely benign
rs2465728005	2:29,001,710	T/A	—	uncertain significance
rs1667091563	2:29,001,718	A/G	—	likely benign
rs1553310744	2:29,001,745	C/A	—	likely pathogenic
rs1558305309	2:29,001,747	A/G	—	uncertain significance
rs1453997983	2:29,001,751	T/C	—	likely benign
rs2465728047	2:29,001,766	T/C	—	likely benign

Showing 100 of 220 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.