PPP2R2C

protein phosphatase 2 regulatory subunit Bgamma

Summary

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Known Variants24 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7606551724:6,325,036A/Guncertain significance
rs3717400904:6,325,120G/Auncertain significance
rs7548374984:6,325,172G/Auncertain significance
rs3750662744:6,325,190C/Tuncertain significance
rs7602516444:6,325,220G/Auncertain significance
rs3676960944:6,325,273C/Tuncertain significance
rs5534608334:6,328,430A/C
rs3688015874:6,335,363T/Cuncertain significance
rs581278424:6,349,563C/Tbenign
rs3718273604:6,349,732C/Guncertain significance
rs9117490264:6,362,109A/G
rs5403439854:6,366,479C/T
rs354106724:6,374,263G/Abenign
rs1394191424:6,377,569G/Tuncertain significance
rs1908386304:6,377,616C/Tuncertain significance
rs24744294654:6,380,229A/Guncertain significance
rs10092002314:6,382,807T/Cuncertain significance
rs1163993324:6,383,507G/Auncertain significance
rs3756331014:6,383,509G/Tuncertain significance
rs1866917724:6,428,903G/Aintron variant
rs622860944:6,502,170C/G
rs1159141024:6,526,279G/Aintron variant
rs5704720924:6,550,953C/T
rs1412527084:6,551,414C/Tregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.