PPP4R4
protein phosphatase 4 regulatory subunit 4
Summary
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201616705 | 14:94,640,839 | A/G | — | uncertain significance |
| rs767422611 | 14:94,640,857 | G/C | — | uncertain significance |
| rs370706599 | 14:94,640,887 | A/G | — | uncertain significance |
| rs747375472 | 14:94,640,897 | G/C | — | uncertain significance |
| rs143741133 | 14:94,657,892 | T/G | intron variant | — |
| rs569713795 | 14:94,669,318 | C/A | — | — |
| rs75992299 | 14:94,680,797 | G/T | — | — |
| rs11848686 | 14:94,680,830 | C/T | intron variant | — |
| rs11160165 | 14:94,689,200 | G/T | intron variant | — |
| rs146647817 | 14:94,691,319 | G/A | intron variant | — |
| rs2504304168 | 14:94,697,017 | T/C | — | uncertain significance |
| rs373815087 | 14:94,697,645 | G/A | — | uncertain significance |
| rs761641862 | 14:94,700,039 | C/A | — | uncertain significance |
| rs1001212064 | 14:94,700,086 | G/C | — | uncertain significance |
| rs2504324393 | 14:94,700,093 | A/T | — | uncertain significance |
| rs749490429 | 14:94,700,976 | G/A | — | uncertain significance |
| rs73344808 | 14:94,702,133 | T/C | — | — |
| rs1892408330 | 14:94,703,916 | A/G | — | uncertain significance |
| rs778681337 | 14:94,708,165 | T/A | — | uncertain significance |
| rs761750084 | 14:94,708,242 | A/T | — | uncertain significance |
| rs766598487 | 14:94,708,633 | T/C | — | uncertain significance |
| rs2504381750 | 14:94,708,668 | C/T | — | uncertain significance |
| rs369067497 | 14:94,708,710 | C/G | — | uncertain significance |
| rs757535001 | 14:94,711,939 | A/G | — | uncertain significance |
| rs369442782 | 14:94,712,838 | C/T | — | uncertain significance |
| rs2504408205 | 14:94,712,870 | G/A | — | uncertain significance |
| rs1021017619 | 14:94,718,151 | G/C | — | uncertain significance |
| rs764922362 | 14:94,718,186 | C/A | — | uncertain significance |
| rs144344963 | 14:94,718,208 | A/G | — | uncertain significance |
| rs1354667092 | 14:94,718,212 | A/G | — | uncertain significance |
| rs777799404 | 14:94,725,683 | G/A | — | uncertain significance |
| rs2504509414 | 14:94,732,165 | C/G | — | uncertain significance |
| rs1306490685 | 14:94,732,176 | A/G | — | uncertain significance |
| rs150367623 | 14:94,733,340 | G/A | — | uncertain significance |
| rs200798794 | 14:94,741,721 | C/A | — | uncertain significance |
| rs773073984 | 14:94,741,722 | C/T | — | uncertain significance |
| rs2504556851 | 14:94,741,744 | T/A | — | uncertain significance |
| rs201604534 | 14:94,741,752 | T/G | — | uncertain significance |
| rs746297591 | 14:94,741,758 | T/C | — | uncertain significance |
| rs149073984 | 14:94,741,777 | C/T | — | uncertain significance |
| rs776455163 | 14:94,741,791 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.