PRAM1
PML-RARA regulated adaptor molecule 1
Summary
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs377607401 | 19:8,555,108 | G/T | — | uncertain significance |
| rs763971313 | 19:8,555,540 | A/G | — | uncertain significance |
| rs372574211 | 19:8,555,577 | C/T | — | uncertain significance |
| rs141653909 | 19:8,555,578 | G/A | — | likely benign |
| rs745481872 | 19:8,555,580 | G/A | — | uncertain significance |
| rs545511903 | 19:8,555,797 | C/T | — | uncertain significance |
| rs2513054447 | 19:8,555,842 | T/C | — | uncertain significance |
| rs1971618420 | 19:8,555,874 | T/C | — | uncertain significance |
| rs372523277 | 19:8,555,989 | C/T | — | likely benign |
| rs1315300334 | 19:8,556,018 | C/A | — | uncertain significance |
| rs2396106 | 19:8,557,139 | T/G | downstream gene variant | — |
| rs184092908 | 19:8,561,132 | T/C | intron variant | — |
| rs759443724 | 19:8,563,122 | G/A | — | uncertain significance |
| rs1971729227 | 19:8,563,143 | A/G | — | uncertain significance |
| rs374625111 | 19:8,563,295 | A/G | — | uncertain significance |
| rs766521799 | 19:8,563,302 | C/T | — | uncertain significance |
| rs779850880 | 19:8,563,364 | G/A | — | uncertain significance |
| rs367671575 | 19:8,563,447 | T/C | — | likely benign |
| rs201139615 | 19:8,563,470 | G/C | — | uncertain significance |
| rs774595612 | 19:8,563,503 | C/T | — | uncertain significance |
| rs765879141 | 19:8,563,649 | G/T | — | uncertain significance |
| rs2513069860 | 19:8,563,668 | G/A | — | uncertain significance |
| rs377529698 | 19:8,563,727 | G/A | — | uncertain significance |
| rs1429761705 | 19:8,563,817 | T/C | — | uncertain significance |
| rs771476394 | 19:8,563,824 | G/A | — | likely benign |
| rs116038361 | 19:8,563,834 | C/T | — | benign |
| rs570407538 | 19:8,563,851 | A/C | — | uncertain significance |
| rs1409803909 | 19:8,563,859 | A/G | — | uncertain significance |
| rs761737505 | 19:8,563,905 | T/C | — | uncertain significance |
| rs80155757 | 19:8,563,912 | G/T | — | benign |
| rs1004931629 | 19:8,563,917 | A/G | — | uncertain significance |
| rs768282181 | 19:8,563,950 | C/T | — | uncertain significance |
| rs2513071328 | 19:8,563,964 | T/C | — | uncertain significance |
| rs200185915 | 19:8,564,000 | G/A | — | uncertain significance |
| rs201237549 | 19:8,564,003 | T/A | — | uncertain significance |
| rs368832868 | 19:8,564,073 | G/T | — | uncertain significance |
| rs2513071919 | 19:8,564,103 | C/T | — | uncertain significance |
| rs1251620026 | 19:8,564,108 | G/C | — | uncertain significance |
| rs763294487 | 19:8,564,109 | G/C | — | uncertain significance |
| rs766664322 | 19:8,564,124 | T/C | — | uncertain significance |
| rs200841911 | 19:8,564,153 | G/C | — | uncertain significance |
| rs761265579 | 19:8,564,170 | A/T | — | uncertain significance |
| rs957160843 | 19:8,564,171 | C/A | — | uncertain significance |
| rs751379944 | 19:8,564,240 | G/A | — | uncertain significance |
| rs754712191 | 19:8,564,244 | C/T | — | uncertain significance |
| rs1371136158 | 19:8,564,289 | C/T | — | uncertain significance |
| rs200799156 | 19:8,564,373 | G/A | — | uncertain significance |
| rs879354850 | 19:8,564,430 | C/A | — | likely benign |
| rs2513073752 | 19:8,564,456 | A/T | — | uncertain significance |
| rs4239540 | 19:8,564,466 | C/A | — | benign |
| rs4990821 | 19:8,564,469 | C/G | — | benign |
| rs4239541 | 19:8,564,474 | G/T | — | benign |
| rs2513074299 | 19:8,564,573 | T/C | — | uncertain significance |
| rs761614956 | 19:8,564,582 | G/A | — | uncertain significance |
| rs117519808 | 19:8,564,611 | C/T | — | benign |
| rs367747523 | 19:8,564,612 | G/C | — | uncertain significance |
| rs534829677 | 19:8,564,645 | C/T | — | uncertain significance |
| rs2967602 | 19:8,569,064 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.