PRDX1
peroxiredoxin 1
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2149325362 | 1:45,977,043 | A/G | — | likely benign |
| rs762370950 | 1:45,977,047 | T/G | — | uncertain significance |
| rs1643741191 | 1:45,977,078 | C/A | — | uncertain significance |
| rs751828470 | 1:45,977,087 | C/A | splice region variant | pathogenic |
| rs1379672870 | 1:45,977,088 | T/A | — | pathogenic |
| rs67683090 | 1:45,977,803 | T/G | downstream gene variant | — |
| rs4660306 | 1:45,978,675 | T/G | — | — |
| rs112554293 | 1:45,980,171 | T/C | — | likely benign |
| rs777677321 | 1:45,980,190 | T/C | — | uncertain significance |
| rs199666364 | 1:45,980,236 | C/G | — | uncertain significance |
| rs775946650 | 1:45,980,252 | G/A | — | likely benign |
| rs369130331 | 1:45,980,319 | G/T | — | likely benign |
| rs367866947 | 1:45,980,536 | A/T | — | likely benign |
| rs1332306016 | 1:45,980,585 | C/G | — | uncertain significance |
| rs777372127 | 1:45,980,588 | G/A | — | uncertain significance |
| rs776067972 | 1:45,980,596 | G/C | — | uncertain significance |
| rs201400424 | 1:45,980,626 | T/C | — | uncertain significance |
| rs533343151 | 1:45,980,630 | T/C | — | uncertain significance |
| rs752317535 | 1:45,980,631 | G/A | — | likely benign |
| rs144310103 | 1:45,980,639 | G/A | — | benign |
| rs2522864533 | 1:45,980,660 | T/G | — | uncertain significance |
| rs759036290 | 1:45,980,669 | T/C | — | uncertain significance |
| rs2356561 | 1:45,980,862 | T/G | — | benign |
| rs35220536 | 1:45,981,108 | G/A | — | benign |
| rs2356560 | 1:45,981,144 | G/A | — | benign |
| rs7516006 | 1:45,981,258 | A/G | — | benign |
| rs34034070 | 1:45,981,402 | T/C | — | uncertain significance |
| rs959844084 | 1:45,981,406 | A/G | — | likely benign |
| rs142590526 | 1:45,981,416 | A/G | — | uncertain significance |
| rs1182536065 | 1:45,981,424 | C/T | — | uncertain significance |
| rs146706025 | 1:45,981,451 | A/G | — | likely benign |
| rs781707654 | 1:45,981,454 | G/A | — | likely benign |
| rs145270179 | 1:45,981,472 | A/G | — | likely benign |
| rs199654232 | 1:45,981,488 | A/T | — | benign |
| rs757405965 | 1:45,981,489 | A/T | — | uncertain significance |
| rs1239079715 | 1:45,981,490 | A/T | — | uncertain significance |
| rs139756090 | 1:45,981,494 | G/A | — | likely benign |
| rs2356559 | 1:45,981,512 | T/C | — | benign |
| rs756556677 | 1:45,984,616 | A/T | — | uncertain significance |
| rs1320203184 | 1:45,984,638 | A/G | — | likely benign |
| rs539081701 | 1:45,984,649 | C/T | — | uncertain significance |
| rs779936396 | 1:45,984,654 | A/G | — | uncertain significance |
| rs368188728 | 1:45,984,658 | C/T | — | uncertain significance |
| rs142967305 | 1:45,984,662 | T/G | — | likely benign |
| rs762465464 | 1:45,984,681 | G/T | — | uncertain significance |
| rs12133294 | 1:45,988,764 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.