PRG3
proteoglycan 3, pro eosinophil major basic protein 2
Summary
An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1856950092 | 11:57,144,330 | G/A | — | uncertain significance |
| rs897769972 | 11:57,144,337 | C/G | — | uncertain significance |
| rs577143930 | 11:57,144,354 | T/C | — | uncertain significance |
| rs115707133 | 11:57,144,356 | G/T | — | likely benign |
| rs754371931 | 11:57,144,381 | C/T | — | uncertain significance |
| rs2846392 | 11:57,144,812 | T/C | intron variant | — |
| rs139866329 | 11:57,145,296 | C/G | missense variant | — |
| rs11229017 | 11:57,145,498 | C/T | intron variant | — |
| rs7107352 | 11:57,145,633 | T/C | intron variant | — |
| rs770001669 | 11:57,147,032 | T/C | — | uncertain significance |
| rs567500232 | 11:57,147,135 | A/C | — | uncertain significance |
| rs140583608 | 11:57,147,155 | C/T | — | uncertain significance |
| rs143922292 | 11:57,147,184 | G/T | — | uncertain significance |
| rs146626344 | 11:57,147,191 | C/A | — | uncertain significance |
| rs1292709695 | 11:57,147,271 | G/A | — | likely benign |
| rs571651 | 11:57,148,053 | G/T | intron variant | — |
| rs764568652 | 11:57,148,106 | A/G | intron variant | — |
| rs769211176 | 11:57,148,160 | G/A | — | uncertain significance |
| rs667864 | 11:57,148,548 | C/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.