PRMT1
protein arginine methyltransferase 1
Summary
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs528130925 | 19:50,179,840 | G/T | — | — |
| rs975484 | 19:50,180,266 | C/G | — | benign |
| rs563347610 | 19:50,183,781 | A/G | — | uncertain significance |
| rs763394313 | 19:50,183,783 | G/C | — | uncertain significance |
| rs79863139 | 19:50,183,788 | G/A | — | benign |
| rs61732965 | 19:50,185,309 | G/A | — | uncertain significance |
| rs1007576675 | 19:50,188,012 | C/T | — | uncertain significance |
| rs985760468 | 19:50,188,072 | G/A | — | uncertain significance |
| rs1310348990 | 19:50,188,280 | G/A | — | uncertain significance |
| rs10415880 | 19:50,189,156 | G/A | upstream gene variant | — |
| rs934096235 | 19:50,189,431 | G/A | — | uncertain significance |
| rs2513966648 | 19:50,189,906 | A/C | — | uncertain significance |
| rs201177531 | 19:50,189,931 | C/T | — | uncertain significance |
| rs149767260 | 19:50,189,932 | G/A | — | likely benign |
| rs368980947 | 19:50,189,942 | A/G | — | uncertain significance |
| rs773048044 | 19:50,191,492 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.