PRRX2
paired related homeobox 2
Summary
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs938263042 | 9:132,428,155 | C/A | — | uncertain significance |
| rs1261831743 | 9:132,428,179 | C/G | — | uncertain significance |
| rs2490997828 | 9:132,428,201 | C/A | — | uncertain significance |
| rs915395706 | 9:132,428,210 | C/G | — | uncertain significance |
| rs751868612 | 9:132,428,285 | G/A | — | uncertain significance |
| rs2490998062 | 9:132,428,292 | T/G | — | uncertain significance |
| rs2490998128 | 9:132,428,322 | C/T | — | uncertain significance |
| rs2119042508 | 9:132,428,337 | A/G | — | uncertain significance |
| rs890419182 | 9:132,428,351 | G/A | — | uncertain significance |
| rs1007476220 | 9:132,428,357 | C/T | — | uncertain significance |
| rs898981546 | 9:132,428,397 | C/T | — | uncertain significance |
| rs7866070 | 9:132,444,099 | A/G | intron variant | — |
| rs138832612 | 9:132,470,478 | C/T | regulatory region variant | — |
| rs777230786 | 9:132,481,525 | C/T | — | uncertain significance |
| rs770826522 | 9:132,481,549 | G/T | — | uncertain significance |
| rs201179051 | 9:132,481,557 | A/C | — | uncertain significance |
| rs775573934 | 9:132,481,567 | G/A | — | uncertain significance |
| rs529534534 | 9:132,481,579 | C/G | — | uncertain significance |
| rs2491067195 | 9:132,481,621 | A/G | — | uncertain significance |
| rs1230797457 | 9:132,481,650 | C/G | — | uncertain significance |
| rs775348667 | 9:132,481,674 | A/G | — | uncertain significance |
| rs202114136 | 9:132,481,683 | G/C | — | uncertain significance |
| rs1484333111 | 9:132,482,951 | T/G | — | uncertain significance |
| rs753647365 | 9:132,482,998 | C/G | — | uncertain significance |
| rs1250052794 | 9:132,483,007 | G/A | — | uncertain significance |
| rs150293718 | 9:132,484,525 | C/T | — | uncertain significance |
| rs2491071911 | 9:132,484,578 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.