PSMD2
proteasome 26S subunit ubiquitin receptor, non-ATPase 2
Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1046699477 | 3:184,017,133 | A/G | — | uncertain significance |
| rs1161247727 | 3:184,017,141 | C/A | — | uncertain significance |
| rs1721567578 | 3:184,017,164 | G/A | — | uncertain significance |
| rs905447773 | 3:184,017,172 | G/A | — | uncertain significance |
| rs376597661 | 3:184,017,694 | G/A | — | uncertain significance |
| rs2473948004 | 3:184,018,200 | A/G | — | uncertain significance |
| rs940815890 | 3:184,018,206 | G/A | — | uncertain significance |
| rs142662907 | 3:184,019,325 | C/T | — | uncertain significance |
| rs148261898 | 3:184,019,326 | G/A | — | uncertain significance |
| rs1721645092 | 3:184,019,364 | A/G | — | uncertain significance |
| rs928649036 | 3:184,019,771 | G/T | — | uncertain significance |
| rs2473950873 | 3:184,019,790 | A/G | — | uncertain significance |
| rs2473950942 | 3:184,019,823 | A/T | — | uncertain significance |
| rs145636508 | 3:184,019,834 | G/A | — | uncertain significance |
| rs779163764 | 3:184,020,195 | C/G | — | uncertain significance |
| rs762633421 | 3:184,020,258 | G/A | — | uncertain significance |
| rs201882149 | 3:184,020,277 | T/C | — | uncertain significance |
| rs1218177632 | 3:184,020,502 | G/A | — | uncertain significance |
| rs764503670 | 3:184,020,838 | C/G | — | uncertain significance |
| rs369135415 | 3:184,020,843 | G/C | — | uncertain significance |
| rs374222348 | 3:184,021,210 | T/A | — | uncertain significance |
| rs201414592 | 3:184,021,448 | G/T | — | uncertain significance |
| rs373839346 | 3:184,021,528 | C/G | — | uncertain significance |
| rs377110401 | 3:184,021,777 | C/T | — | uncertain significance |
| rs7618629 | 3:184,023,061 | A/G | intron variant | — |
| rs1203901646 | 3:184,023,588 | G/A | — | uncertain significance |
| rs568218191 | 3:184,024,263 | G/A | — | uncertain significance |
| rs757881754 | 3:184,024,276 | C/G | — | uncertain significance |
| rs11545175 | 3:184,025,306 | G/A | — | likely benign |
| rs761920819 | 3:184,025,732 | C/T | — | uncertain significance |
| rs374233208 | 3:184,025,742 | T/G | — | uncertain significance |
| rs2473963112 | 3:184,026,257 | T/C | — | uncertain significance |
| rs114877343 | 3:184,026,665 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.