PTGER4
prostaglandin E receptor 4
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs45613037 | 5:40,679,845 | A/G | — | benign |
| rs768268072 | 5:40,681,135 | C/G | — | uncertain significance |
| rs2530875743 | 5:40,681,351 | C/T | — | uncertain significance |
| rs146108114 | 5:40,681,561 | A/C | — | uncertain significance |
| rs2111783400 | 5:40,681,626 | C/A | — | uncertain significance |
| rs1194756022 | 5:40,681,654 | A/G | — | uncertain significance |
| rs2530877237 | 5:40,681,693 | G/A | — | uncertain significance |
| rs778925464 | 5:40,681,807 | T/A | — | uncertain significance |
| rs1392141151 | 5:40,681,817 | A/C | — | uncertain significance |
| rs2530877835 | 5:40,681,857 | T/G | — | uncertain significance |
| rs111866313 | 5:40,691,893 | A/G | — | benign |
| rs2530896753 | 5:40,692,025 | A/C | — | uncertain significance |
| rs188541458 | 5:40,692,084 | G/T | — | likely benign |
| rs746319512 | 5:40,692,350 | A/G | — | uncertain significance |
| rs143634967 | 5:40,692,394 | G/A | — | likely benign |
| rs6872282 | 5:40,704,090 | C/A | — | — |
| rs149374052 | 5:40,707,373 | G/A | intergenic variant | — |
| rs10061303 | 5:40,708,369 | G/C | — | — |
| rs6897169 | 5:40,726,138 | C/A | — | — |
| rs6860328 | 5:40,729,974 | T/C | intron variant | — |
| rs3805497 | 5:40,746,885 | A/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.