PTP4A3
protein tyrosine phosphatase 4A3
Summary
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7824029 | 8:142,412,478 | T/A | regulatory region variant | — |
| rs34642025 | 8:142,415,650 | A/T | — | — |
| rs116877855 | 8:142,418,417 | C/T | intron variant | — |
| rs201548699 | 8:142,432,338 | G/T | — | likely benign |
| rs745344665 | 8:142,432,422 | G/A | — | uncertain significance |
| rs2537615249 | 8:142,435,159 | G/T | — | uncertain significance |
| rs757028048 | 8:142,435,209 | C/T | — | uncertain significance |
| rs74648509 | 8:142,437,034 | C/T | — | benign |
| rs2537683923 | 8:142,437,076 | A/G | — | uncertain significance |
| rs1255478847 | 8:142,437,129 | G/A | — | uncertain significance |
| rs765227210 | 8:142,437,147 | C/T | — | uncertain significance |
| rs1241185896 | 8:142,437,905 | G/A | — | uncertain significance |
| rs145157893 | 8:142,441,034 | C/T | — | uncertain significance |
| rs754768750 | 8:142,441,098 | G/A | — | uncertain significance |
| rs1833848551 | 8:142,441,109 | C/T | — | uncertain significance |
| rs1563743999 | 8:142,441,115 | A/C | — | uncertain significance |
| rs140223999 | 8:142,441,116 | C/T | — | uncertain significance |
| rs2537829301 | 8:142,441,134 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.