PTPRG
protein tyrosine phosphatase receptor type G
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Known Variants120 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1313122480 | 3:61,547,966 | G/A | — | uncertain significance |
| rs776348805 | 3:61,547,987 | G/C | — | uncertain significance |
| rs77802872 | 3:61,548,001 | C/T | — | benign |
| rs140017853 | 3:61,548,010 | A/G | — | uncertain significance |
| rs758281367 | 3:61,548,019 | G/C | — | uncertain significance |
| rs745504638 | 3:61,548,032 | T/C | — | uncertain significance |
| rs7433083 | 3:61,549,659 | T/G | — | — |
| rs13090765 | 3:61,591,245 | T/G | — | — |
| rs75577896 | 3:61,634,437 | G/T | intron variant | — |
| rs200002839 | 3:61,734,552 | C/T | — | uncertain significance |
| rs371539304 | 3:61,734,589 | T/A | — | uncertain significance |
| rs1179424376 | 3:61,734,602 | G/A | — | uncertain significance |
| rs753443145 | 3:61,734,635 | G/A | — | uncertain significance |
| rs77715924 | 3:61,734,640 | G/A | — | benign |
| rs190597312 | 3:61,755,001 | A/G | intron variant | — |
| rs652889 | 3:61,794,054 | C/G | — | — |
| rs682580 | 3:61,830,423 | C/G | — | — |
| rs13092452 | 3:61,926,327 | A/C | — | — |
| rs6769017 | 3:61,935,805 | T/A | — | — |
| rs760184818 | 3:61,975,305 | A/C | — | uncertain significance |
| rs141896316 | 3:61,975,391 | G/T | — | uncertain significance |
| rs2471287718 | 3:61,975,422 | A/T | — | uncertain significance |
| rs201085188 | 3:61,975,433 | A/G | — | uncertain significance |
| rs251036 | 3:61,978,385 | A/G | intron variant | — |
| rs111999284 | 3:61,981,360 | T/C | — | — |
| rs140777402 | 3:61,989,028 | A/G | — | uncertain significance |
| rs1165690037 | 3:61,989,080 | T/A | — | uncertain significance |
| rs201734186 | 3:61,989,119 | A/G | — | uncertain significance |
| rs757115800 | 3:61,989,122 | G/T | — | uncertain significance |
| rs374973218 | 3:61,989,145 | A/G | — | uncertain significance |
| rs372067576 | 3:61,989,149 | A/G | — | uncertain significance |
| rs2107561 | 3:61,993,536 | G/A | intron variant | — |
| rs10490775 | 3:62,036,724 | C/T | intron variant | — |
| rs17767746 | 3:62,037,015 | G/T | intron variant | — |
| rs9311835 | 3:62,044,608 | C/T | intron variant | — |
| rs535128090 | 3:62,058,954 | C/T | — | — |
| rs373688958 | 3:62,063,888 | A/G | — | uncertain significance |
| rs11130874 | 3:62,064,769 | A/G | intron variant | — |
| rs9855037 | 3:62,070,329 | C/T | regulatory region variant | — |
| rs570133583 | 3:62,077,230 | G/A | — | — |
| rs35593266 | 3:62,112,141 | G/A | upstream gene variant | — |
| rs754085336 | 3:62,118,280 | G/C | — | uncertain significance |
| rs188991589 | 3:62,118,319 | G/C | — | uncertain significance |
| rs760188470 | 3:62,142,832 | A/G | — | likely benign |
| rs1342159175 | 3:62,153,651 | G/T | — | uncertain significance |
| rs2529096432 | 3:62,177,220 | G/A | — | uncertain significance |
| rs2529096565 | 3:62,177,239 | C/G | — | uncertain significance |
| rs113199298 | 3:62,177,285 | C/T | — | likely benign |
| rs764590925 | 3:62,177,299 | C/T | — | uncertain significance |
| rs535321914 | 3:62,177,322 | G/A | — | uncertain significance |
| rs7650104 | 3:62,180,753 | T/C | — | benign |
| rs773365125 | 3:62,180,799 | C/T | — | uncertain significance |
| rs112710255 | 3:62,180,804 | C/T | — | likely benign |
| rs759728947 | 3:62,180,809 | T/C | — | uncertain significance |
| rs763904315 | 3:62,180,816 | C/T | — | likely benign |
| rs1241673598 | 3:62,188,934 | T/G | — | uncertain significance |
| rs757694918 | 3:62,188,997 | G/C | — | uncertain significance |
| rs376410542 | 3:62,189,011 | G/A | — | likely benign |
| rs764776482 | 3:62,189,021 | G/A | — | uncertain significance |
| rs151090262 | 3:62,189,086 | G/A | — | likely benign |
| rs775496767 | 3:62,189,112 | C/T | — | uncertain significance |
| rs1467963955 | 3:62,189,122 | A/T | — | likely benign |
| rs192743559 | 3:62,189,130 | C/A | — | uncertain significance |
| rs201820508 | 3:62,189,151 | C/A | — | uncertain significance |
| rs754318982 | 3:62,189,162 | G/C | — | uncertain significance |
| rs201733832 | 3:62,189,172 | C/T | — | uncertain significance |
| rs141789888 | 3:62,189,205 | A/G | — | uncertain significance |
| rs369979250 | 3:62,189,255 | G/A | — | uncertain significance |
| rs1433488876 | 3:62,189,279 | G/A | — | uncertain significance |
| rs372453824 | 3:62,189,300 | G/A | — | uncertain significance |
| rs375771680 | 3:62,189,309 | G/A | — | uncertain significance |
| rs764187290 | 3:62,189,351 | T/G | — | uncertain significance |
| rs1700151223 | 3:62,189,360 | A/G | — | uncertain significance |
| rs143827266 | 3:62,189,362 | C/T | — | likely benign |
| rs377266213 | 3:62,189,372 | G/A | — | uncertain significance |
| rs761975908 | 3:62,189,420 | G/A | — | likely benign |
| rs140914977 | 3:62,189,432 | C/G | — | uncertain significance |
| rs1338636038 | 3:62,189,453 | G/A | — | uncertain significance |
| rs561879723 | 3:62,189,506 | C/T | — | likely benign |
| rs1417328865 | 3:62,189,576 | C/T | — | uncertain significance |
| rs750425296 | 3:62,189,582 | G/T | — | uncertain significance |
| rs757650773 | 3:62,204,595 | T/G | — | uncertain significance |
| rs919959614 | 3:62,204,623 | C/G | — | uncertain significance |
| rs1380159044 | 3:62,216,937 | G/A | — | uncertain significance |
| rs780013182 | 3:62,229,501 | A/G | — | uncertain significance |
| rs776124375 | 3:62,229,566 | A/C | — | uncertain significance |
| rs548221148 | 3:62,240,806 | G/A | — | uncertain significance |
| rs1576182730 | 3:62,240,835 | A/G | — | uncertain significance |
| rs561653746 | 3:62,248,483 | G/A | — | uncertain significance |
| rs2529295270 | 3:62,253,109 | G/T | — | uncertain significance |
| rs775266617 | 3:62,253,429 | A/G | — | uncertain significance |
| rs201115216 | 3:62,254,771 | C/T | — | uncertain significance |
| rs764384969 | 3:62,257,083 | G/A | — | uncertain significance |
| rs913861646 | 3:62,257,164 | T/C | — | uncertain significance |
| rs150212631 | 3:62,257,194 | G/A | — | likely benign |
| rs2529305842 | 3:62,257,229 | A/G | — | uncertain significance |
| rs138240632 | 3:62,258,649 | A/G | — | uncertain significance |
| rs148186037 | 3:62,258,700 | G/A | — | benign |
| rs778044422 | 3:62,258,719 | A/G | — | uncertain significance |
| rs371762103 | 3:62,258,732 | G/C | — | uncertain significance |
Showing 100 of 120 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.