QRSL1

glutaminyl-tRNA amidotransferase subunit QRSL1

Summary

Contributes to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants113 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3747791	6:107,077,408	C/T	—	benign
rs2054365	6:107,077,502	G/A	—	benign
rs3747792	6:107,077,550	G/A	—	benign
rs781233024	6:107,077,566	C/T	—	uncertain significance
rs373031772	6:107,077,572	C/T	—	uncertain significance
rs142692484	6:107,077,577	A/C	—	likely benign
rs376227484	6:107,077,578	G/C	—	uncertain significance
rs111609677	6:107,077,597	C/T	—	benign
rs570669053	6:107,077,600	T/A	—	likely benign
rs36016898	6:107,088,231	C/T	—	benign
rs117167190	6:107,088,232	G/A	—	likely benign
rs368730240	6:107,088,245	G/A	—	uncertain significance
rs766019540	6:107,088,274	A/G	—	likely benign
rs758616388	6:107,088,340	G/A	—	likely benign
rs1171931506	6:107,088,372	G/T	—	uncertain significance
rs1777000992	6:107,088,376	T/C	—	likely benign
rs746509227	6:107,088,380	A/G	—	uncertain significance
rs2306098	6:107,088,585	T/A	—	benign
rs367555359	6:107,088,736	G/A	—	uncertain significance
rs200164281	6:107,088,737	T/C	—	uncertain significance
rs56974135	6:107,088,768	G/A	—	benign
rs771724047	6:107,088,799	A/G	—	uncertain significance
rs745378603	6:107,090,858	A/T	—	likely benign
rs540641125	6:107,090,869	G/A	—	uncertain significance
rs560482009	6:107,090,905	A/C	—	uncertain significance
rs2482496825	6:107,090,924	T/C	—	likely benign
rs1777047446	6:107,090,935	G/A	—	pathogenic
rs2114704582	6:107,090,940	A/G	—	uncertain significance
rs1209965078	6:107,090,948	A/G	—	likely benign
rs9486434	6:107,096,853	A/C	—	benign
rs113197359	6:107,096,884	T/A	—	likely benign
rs760780607	6:107,096,891	C/T	—	likely benign
rs367766803	6:107,096,892	G/A	—	benign
rs1562168768	6:107,096,917	G/T	—	pathogenic
rs891606362	6:107,096,994	G/A	—	uncertain significance
rs751111258	6:107,097,002	A/G	—	likely benign
rs79895740	6:107,097,059	G/A	—	benign
rs765545478	6:107,097,063	T/C	—	uncertain significance
rs763443331	6:107,097,074	C/A	—	pathogenic
rs768184246	6:107,100,111	G/A	—	likely benign
rs201077509	6:107,100,175	C/T	—	uncertain significance
rs761098365	6:107,100,203	C/T	—	uncertain significance
rs112965704	6:107,100,204	G/A	—	benign
rs144555270	6:107,100,212	T/G	—	likely benign
rs144191952	6:107,100,220	A/G	—	benign
rs201592456	6:107,100,353	G/A	—	uncertain significance
rs761379461	6:107,100,364	C/T	—	likely benign
rs148734046	6:107,100,369	A/T	—	uncertain significance
rs142361530	6:107,100,385	T/C	—	likely benign
rs34221917	6:107,100,396	A/G	—	benign
rs146630103	6:107,100,397	T/C	—	benign
rs746018325	6:107,100,406	C/A	—	uncertain significance
rs762322256	6:107,100,437	C/G	—	uncertain significance
rs144453885	6:107,100,438	T/G	—	uncertain significance
rs2482516211	6:107,100,452	C/G	—	uncertain significance
rs6925169	6:107,100,483	C/T	—	benign
rs182715308	6:107,100,529	A/C	—	likely benign
rs201614446	6:107,102,600	A/G	—	conflicting classifications of pathogenicity
rs947204455	6:107,102,602	A/G	—	pathogenic
rs1216388009	6:107,102,614	G/A	—	conflicting classifications of pathogenicity
rs139097179	6:107,102,618	C/T	—	likely benign
rs751667243	6:107,102,619	G/A	—	likely benign
rs1582417711	6:107,102,635	G/C	—	uncertain significance
rs137929985	6:107,102,651	C/T	—	uncertain significance
rs2482520912	6:107,102,689	G/A	—	uncertain significance
rs375665232	6:107,102,743	T/C	—	likely benign
rs2482521109	6:107,102,749	A/G	—	uncertain significance
rs143085016	6:107,102,766	G/A	—	uncertain significance
rs2482521210	6:107,102,780	T/C	—	uncertain significance
rs6911321	6:107,103,479	C/T	—	benign
rs1562170963	6:107,103,490	G/A	—	uncertain significance
rs148231578	6:107,103,496	G/A	—	likely benign
rs754249822	6:107,103,505	T/C	—	uncertain significance
rs2482522709	6:107,103,509	T/C	—	likely benign
rs118029715	6:107,103,510	T/G	—	benign
rs757923935	6:107,103,525	A/G	—	uncertain significance
rs143151340	6:107,103,537	A/G	—	conflicting classifications of pathogenicity
rs138471223	6:107,103,539	C/T	—	likely benign
rs72946534	6:107,103,544	G/A	—	conflicting classifications of pathogenicity
rs918445566	6:107,103,579	C/T	—	uncertain significance
rs375529968	6:107,103,615	A/G	—	uncertain significance
rs146640596	6:107,103,621	T/G	—	benign
rs150607276	6:107,110,855	A/C	—	likely benign
rs2482537684	6:107,110,866	A/G	—	uncertain significance
rs376018861	6:107,110,895	C/A	—	uncertain significance
rs777858343	6:107,110,898	C/G	—	uncertain significance
rs528085772	6:107,110,906	T/C	—	benign
rs765596479	6:107,110,915	T/C	—	likely benign
rs749316210	6:107,110,931	T/C	—	uncertain significance
rs777579369	6:107,110,980	C/G	—	uncertain significance
rs140028828	6:107,110,988	G/A	—	likely benign
rs747078658	6:107,110,997	A/G	—	uncertain significance
rs1282702623	6:107,111,045	G/T	—	uncertain significance
rs1313036130	6:107,111,046	C/A	—	uncertain significance
rs763475526	6:107,111,054	A/G	—	uncertain significance
rs72613241	6:107,111,084	T/G	—	benign
rs1026621	6:107,113,403	T/G	—	benign
rs3121448	6:107,113,509	A/G	—	benign
rs17067608	6:107,113,618	G/A	—	benign
rs1235682851	6:107,113,708	T/C	—	uncertain significance

Showing 100 of 113 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.