RABGEF1

RAB guanine nucleotide exchange factor 1

Summary

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]

Known Variants22 total

rsidPosition (GRCh37)AllelesClassClinVar
rs126726407:66,203,010G/A
rs12973288317:66,235,227T/G
rs5663656277:66,237,060G/Alikely benign
rs3736815487:66,240,351G/Tuncertain significance
rs25364329007:66,248,673G/Auncertain significance
rs25364334657:66,248,722A/Tuncertain significance
rs7522659777:66,248,818A/Guncertain significance
rs7813996667:66,260,564C/Guncertain significance
rs7738855147:66,264,327C/Tuncertain significance
rs5653752367:66,264,353A/Guncertain significance
rs7504816957:66,270,160G/Auncertain significance
rs7668256677:66,270,174T/Guncertain significance
rs1447792947:66,270,205A/Glikely benign
rs17881732277:66,270,211T/Auncertain significance
rs25366860977:66,270,270A/Guncertain significance
rs7530770717:66,270,323G/Clikely benign
rs10455908727:66,270,324C/Tuncertain significance
rs7776859467:66,273,942C/Tuncertain significance
rs7754134727:66,273,966C/Tuncertain significance
rs3738217947:66,273,992G/Tuncertain significance
rs2001121677:66,274,027A/Guncertain significance
rs12863222957:66,274,168T/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.