RAD1
RAD1 checkpoint DNA exonuclease
Summary
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1805327 | 5:34,908,877 | T/C | — | benign |
| rs767339733 | 5:34,908,920 | C/G | — | uncertain significance |
| rs1580505534 | 5:34,908,929 | T/C | — | uncertain significance |
| rs372896762 | 5:34,908,936 | A/G | — | likely benign |
| rs1561168024 | 5:34,908,989 | G/A | — | uncertain significance |
| rs2308953 | 5:34,909,062 | G/C | — | benign |
| rs77501359 | 5:34,909,420 | T/C | — | likely benign |
| rs150210504 | 5:34,909,421 | A/C | — | uncertain significance |
| rs370172915 | 5:34,911,674 | T/A | — | uncertain significance |
| rs373845802 | 5:34,911,704 | C/T | — | uncertain significance |
| rs147296059 | 5:34,911,706 | C/T | — | likely benign |
| rs779895655 | 5:34,911,707 | G/C | — | uncertain significance |
| rs764156346 | 5:34,911,734 | C/T | — | uncertain significance |
| rs747869392 | 5:34,911,738 | G/C | — | uncertain significance |
| rs762520471 | 5:34,911,758 | A/G | — | uncertain significance |
| rs2111942739 | 5:34,911,803 | T/C | — | uncertain significance |
| rs751552145 | 5:34,911,822 | T/G | — | uncertain significance |
| rs755896066 | 5:34,911,851 | T/C | — | uncertain significance |
| rs2308957 | 5:34,911,884 | C/T | — | benign |
| rs113022677 | 5:34,911,899 | C/T | — | uncertain significance |
| rs2308956 | 5:34,911,900 | G/A | — | uncertain significance |
| rs1805328 | 5:34,911,914 | G/C | — | benign |
| rs141639726 | 5:34,913,603 | T/C | — | likely benign |
| rs919885394 | 5:34,913,609 | G/C | — | uncertain significance |
| rs778408828 | 5:34,913,638 | A/G | — | uncertain significance |
| rs200798685 | 5:34,913,687 | T/C | — | likely benign |
| rs530557961 | 5:34,914,849 | T/C | — | uncertain significance |
| rs1295336557 | 5:34,914,991 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.