RAPGEF6
Rap guanine nucleotide exchange factor 6
Summary
Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants96 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201795942 | 5:130,762,964 | C/G | — | uncertain significance |
| rs138602956 | 5:130,764,696 | G/A | — | uncertain significance |
| rs1064539 | 5:130,764,699 | A/T | — | benign |
| rs759081697 | 5:130,764,736 | A/G | — | uncertain significance |
| rs898285861 | 5:130,764,756 | T/A | — | uncertain significance |
| rs149517739 | 5:130,764,798 | T/A | — | uncertain significance |
| rs202220211 | 5:130,764,825 | G/A | — | uncertain significance |
| rs766800773 | 5:130,764,880 | C/T | — | uncertain significance |
| rs73786670 | 5:130,766,542 | C/A | — | benign |
| rs34020762 | 5:130,766,622 | G/T | — | benign |
| rs2532245114 | 5:130,766,815 | G/A | — | uncertain significance |
| rs150501049 | 5:130,766,905 | C/T | — | uncertain significance |
| rs531382309 | 5:130,766,944 | G/A | — | uncertain significance |
| rs141687018 | 5:130,767,038 | T/C | — | uncertain significance |
| rs369864774 | 5:130,769,142 | G/C | — | uncertain significance |
| rs1751832370 | 5:130,769,159 | G/A | — | uncertain significance |
| rs1751838893 | 5:130,769,235 | G/C | — | uncertain significance |
| rs761065851 | 5:130,769,351 | C/T | — | uncertain significance |
| rs142796197 | 5:130,775,403 | T/C | — | uncertain significance |
| rs146056349 | 5:130,778,071 | T/G | — | uncertain significance |
| rs143950498 | 5:130,778,127 | G/A | — | benign |
| rs750028606 | 5:130,778,228 | T/G | — | uncertain significance |
| rs767063387 | 5:130,782,179 | T/C | — | uncertain significance |
| rs780359039 | 5:130,782,239 | C/G | — | uncertain significance |
| rs989837877 | 5:130,782,274 | G/A | — | uncertain significance |
| rs1247205593 | 5:130,782,275 | C/T | — | uncertain significance |
| rs759203693 | 5:130,782,301 | T/C | — | uncertain significance |
| rs1184105930 | 5:130,782,322 | C/T | — | uncertain significance |
| rs370167710 | 5:130,782,337 | T/C | — | uncertain significance |
| rs1480481724 | 5:130,785,722 | C/G | — | uncertain significance |
| rs201609671 | 5:130,785,725 | C/T | — | uncertain significance |
| rs1048532581 | 5:130,785,726 | G/A | — | uncertain significance |
| rs766809006 | 5:130,788,753 | C/T | — | uncertain significance |
| rs764241580 | 5:130,788,799 | C/T | — | uncertain significance |
| rs550513672 | 5:130,788,804 | C/T | — | uncertain significance |
| rs775935438 | 5:130,791,557 | T/C | — | uncertain significance |
| rs1753458028 | 5:130,791,559 | C/T | — | uncertain significance |
| rs147549876 | 5:130,791,624 | A/G | — | benign |
| rs369473445 | 5:130,791,632 | G/T | — | uncertain significance |
| rs149061730 | 5:130,791,649 | C/G | — | uncertain significance |
| rs372487065 | 5:130,797,437 | C/T | — | uncertain significance |
| rs755262978 | 5:130,797,557 | C/G | — | uncertain significance |
| rs138160991 | 5:130,797,609 | T/G | — | uncertain significance |
| rs765584713 | 5:130,797,654 | T/C | — | uncertain significance |
| rs1159572245 | 5:130,797,677 | A/G | — | uncertain significance |
| rs764626082 | 5:130,797,688 | C/G | — | uncertain significance |
| rs2532346429 | 5:130,797,706 | G/C | — | uncertain significance |
| rs1368635078 | 5:130,797,721 | T/G | — | uncertain significance |
| rs770522345 | 5:130,799,887 | A/G | — | uncertain significance |
| rs200228047 | 5:130,799,942 | C/G | — | uncertain significance |
| rs752515177 | 5:130,799,971 | A/G | — | uncertain significance |
| rs1441863912 | 5:130,808,322 | G/C | — | uncertain significance |
| rs144719032 | 5:130,808,381 | C/T | — | uncertain significance |
| rs2532388962 | 5:130,808,391 | T/C | — | uncertain significance |
| rs924727565 | 5:130,808,436 | C/A | — | uncertain significance |
| rs2532409342 | 5:130,815,219 | G/A | — | uncertain significance |
| rs148528529 | 5:130,815,338 | C/A | — | uncertain significance |
| rs2532444995 | 5:130,825,301 | T/C | — | uncertain significance |
| rs774851541 | 5:130,828,327 | C/G | — | uncertain significance |
| rs368164117 | 5:130,828,393 | C/A | — | uncertain significance |
| rs1756367085 | 5:130,828,443 | G/C | — | likely benign |
| rs771044257 | 5:130,828,459 | C/T | — | uncertain significance |
| rs140676026 | 5:130,831,341 | C/T | — | uncertain significance |
| rs31251 | 5:130,833,946 | C/T | intron variant | — |
| rs748347202 | 5:130,834,170 | A/G | — | uncertain significance |
| rs746773756 | 5:130,834,269 | A/G | — | uncertain significance |
| rs1377384568 | 5:130,834,282 | T/C | — | uncertain significance |
| rs2532492355 | 5:130,840,330 | T/C | — | uncertain significance |
| rs1454912075 | 5:130,840,354 | G/A | — | uncertain significance |
| rs145502622 | 5:130,840,365 | C/A | — | uncertain significance |
| rs201819833 | 5:130,841,167 | G/A | — | uncertain significance |
| rs552989825 | 5:130,843,787 | T/C | — | likely benign |
| rs1757482983 | 5:130,843,804 | A/G | — | uncertain significance |
| rs2532504406 | 5:130,843,884 | A/C | — | uncertain significance |
| rs1378626537 | 5:130,846,066 | C/T | — | uncertain significance |
| rs757389222 | 5:130,846,091 | C/G | — | uncertain significance |
| rs770004750 | 5:130,846,112 | C/T | — | uncertain significance |
| rs116131520 | 5:130,846,190 | A/C | — | likely benign |
| rs2532547089 | 5:130,857,136 | C/T | — | uncertain significance |
| rs529227000 | 5:130,857,144 | C/G | — | uncertain significance |
| rs1758475572 | 5:130,857,189 | T/C | — | uncertain significance |
| rs571832857 | 5:130,857,582 | A/T | — | — |
| rs199832508 | 5:130,859,486 | A/C | — | — |
| rs2189383 | 5:130,861,874 | T/G | — | — |
| rs1029472 | 5:130,867,733 | G/T | — | — |
| rs140883805 | 5:130,883,741 | G/C | — | uncertain significance |
| rs144946919 | 5:130,883,750 | C/G | — | uncertain significance |
| rs780226862 | 5:130,883,808 | G/A | — | uncertain significance |
| rs1760672775 | 5:130,883,835 | G/A | — | uncertain significance |
| rs2531928119 | 5:130,928,146 | C/T | — | uncertain significance |
| rs140289609 | 5:130,939,019 | A/C | — | uncertain significance |
| rs75953559 | 5:130,941,741 | A/G | intron variant | — |
| rs3756290 | 5:130,951,750 | A/G | intron variant | — |
| rs11950815 | 5:130,955,487 | G/A | intron variant | — |
| rs576014852 | 5:130,970,657 | C/G | — | uncertain significance |
| rs1352482682 | 5:130,970,714 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.