RARRES1
retinoic acid receptor responder 1
Summary
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs779301244 | 3:158,415,489 | G/A | — | uncertain significance |
| rs938058778 | 3:158,415,517 | C/T | — | uncertain significance |
| rs1299495383 | 3:158,415,523 | C/A | — | uncertain significance |
| rs780550373 | 3:158,415,534 | G/A | — | uncertain significance |
| rs2473080765 | 3:158,415,590 | C/A | — | uncertain significance |
| rs1726600411 | 3:158,415,741 | T/G | — | uncertain significance |
| rs73030851 | 3:158,416,952 | A/G | downstream gene variant | — |
| rs140091959 | 3:158,422,600 | G/A | — | uncertain significance |
| rs145290079 | 3:158,422,635 | A/G | — | uncertain significance |
| rs1559870741 | 3:158,428,601 | C/A | — | uncertain significance |
| rs373892436 | 3:158,428,626 | T/A | — | uncertain significance |
| rs148853178 | 3:158,431,609 | T/C | — | uncertain significance |
| rs544435542 | 3:158,431,618 | C/T | — | uncertain significance |
| rs1007383760 | 3:158,431,630 | A/G | — | uncertain significance |
| rs2279561 | 3:158,431,702 | A/G | — | — |
| rs531801404 | 3:158,440,356 | T/C | — | — |
| rs1024581644 | 3:158,449,960 | A/C | — | uncertain significance |
| rs373683910 | 3:158,449,963 | C/A | — | uncertain significance |
| rs1354953640 | 3:158,449,982 | C/A | — | uncertain significance |
| rs1421444552 | 3:158,449,985 | A/G | — | uncertain significance |
| rs1208731972 | 3:158,449,996 | A/T | — | uncertain significance |
| rs1461964719 | 3:158,450,059 | G/A | — | uncertain significance |
| rs2473130484 | 3:158,450,068 | G/C | — | uncertain significance |
| rs7621322 | 3:158,450,080 | T/G | — | uncertain significance |
| rs1474623208 | 3:158,450,081 | C/G | — | uncertain significance |
| rs1194657718 | 3:158,450,087 | A/C | — | uncertain significance |
| rs754539084 | 3:158,450,171 | A/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.