REM1

RRAD and GEM like GTPase 1

Summary

The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

Known Variants24 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs375889740	20:30,064,298	C/T	—	uncertain significance
rs372672371	20:30,064,307	C/T	—	uncertain significance
rs761200099	20:30,064,340	G/C	—	uncertain significance
rs543891151	20:30,064,382	G/A	—	uncertain significance
rs111596332	20:30,064,462	G/A	missense variant	—
rs368718267	20:30,064,474	T/C	—	uncertain significance
rs757000852	20:30,064,493	G/A	—	uncertain significance
rs773658231	20:30,064,549	G/C	—	uncertain significance
rs754478340	20:30,064,583	T/C	—	uncertain significance
rs746305275	20:30,065,636	G/A	—	uncertain significance
rs200326863	20:30,065,694	C/G	—	uncertain significance
rs533943104	20:30,065,705	G/A	—	uncertain significance
rs113549370	20:30,068,798	G/A	upstream gene variant	—
rs2515293875	20:30,070,190	T/C	—	uncertain significance
rs749610862	20:30,070,205	G/A	—	uncertain significance
rs768768449	20:30,070,237	A/C	—	uncertain significance
rs550409143	20:30,070,243	G/A	—	likely benign
rs752009654	20:30,070,274	G/A	—	uncertain significance
rs754841342	20:30,071,979	G/A	—	uncertain significance
rs749183464	20:30,072,042	T/A	—	uncertain significance
rs2233835	20:30,072,093	A/G	—	benign
rs1205580643	20:30,072,099	C/A	—	uncertain significance
rs2122485672	20:30,072,195	G/A	—	uncertain significance
rs1487226257	20:30,072,223	C/A	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.