REPS2

RALBP1 associated Eps domain containing 2

Summary

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants37 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2060437289X:16,964,998C/Tuncertain significance
rs1047952328X:16,965,023A/Glikely benign
rs867415979X:16,965,025C/Tuncertain significance
rs942128328X:16,965,094G/Auncertain significance
rs2060441927X:16,965,114C/Guncertain significance
rs996210768X:16,965,144G/Cuncertain significance
rs1170776719X:16,965,145G/Cuncertain significance
rs747915100X:16,965,163C/Tlikely benign
rs891072078X:16,965,184C/Guncertain significance
rs763632604X:16,965,201G/Alikely benign
rs2518555847X:16,965,253A/Guncertain significance
rs5924566X:16,978,254A/C
rs772735900X:17,024,446C/Tuncertain significance
rs1339157602X:17,040,318A/Guncertain significance
rs2518861610X:17,040,372G/Cuncertain significance
rs777305301X:17,040,377G/Auncertain significance
rs373958763X:17,043,234C/Tuncertain significance
rs144810333X:17,047,675G/Tuncertain significance
rs753183113X:17,047,680G/Alikely benign
rs370804178X:17,047,684G/Auncertain significance
rs149335477X:17,047,697C/Tuncertain significance
rs768733696X:17,047,709G/Auncertain significance
rs6629201X:17,068,163C/Tintron variant
rs770109996X:17,080,611T/Cuncertain significance
rs147267823X:17,080,618C/Tuncertain significance
rs181282465X:17,086,548T/Clikely benign
rs147520826X:17,088,077A/Guncertain significance
rs754985513X:17,152,013A/Guncertain significance
rs755798856X:17,153,405C/Tuncertain significance
rs868000265X:17,153,469C/Tuncertain significance
rs1289562701X:17,153,471A/Guncertain significance
rs770010053X:17,153,496C/Tlikely benign
rs2519396009X:17,156,990A/Cuncertain significance
rs2519396028X:17,156,992C/Tuncertain significance
rs140955532X:17,157,027T/Cbenign
rs1397691843X:17,165,589G/Alikely benign
rs187573797X:17,205,500A/Glikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.