REST

RE1 silencing transcription factor

Summary

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

Known Variants534 total

rsidPosition (GRCh37)AllelesClassClinVar
rs667907034:57,773,908G/C——
rs68531564:57,774,843C/A——
rs350559524:57,776,515A/G—benign
rs21095223924:57,776,808G/A—uncertain significance
rs9981520624:57,776,846G/A—likely benign
rs10299863804:57,776,847C/G—uncertain significance
rs7552797914:57,776,856A/C—uncertain significance
rs24757973674:57,776,866A/G—uncertain significance
rs3755118944:57,776,872G/A—uncertain significance
rs7773689204:57,776,874A/G—uncertain significance
rs24757974394:57,776,879C/T—likely benign
rs9488338884:57,776,889G/A—uncertain significance
rs24757974804:57,776,891C/A—uncertain significance
rs7587257444:57,776,892A/G—uncertain significance
rs24757974904:57,776,893T/C—uncertain significance
rs21095225814:57,776,894G/T—uncertain significance
rs9677441144:57,776,896A/G—uncertain significance
rs7475269054:57,776,900C/T—likely benign
rs17198549674:57,776,905A/G—uncertain significance
rs5537868294:57,776,915C/G—likely benign
rs13886614604:57,776,928G/A—uncertain significance
rs21095226954:57,776,933A/G—likely benign
rs24757976544:57,776,935C/G—uncertain significance
rs24757976794:57,776,940C/G—uncertain significance
rs13503062184:57,776,951G/A—likely benign
rs21095227384:57,776,954A/T—likely benign
rs24757977374:57,776,955A/G—uncertain significance
rs17198570644:57,776,961G/T—uncertain significance
rs7638664404:57,776,975A/G—likely benign
rs7655219014:57,777,005C/A—likely benign
rs3770807324:57,777,018C/A—uncertain significance
rs24757979834:57,777,020G/T—uncertain significance
rs13735186934:57,777,026A/G—likely benign
rs1425048294:57,777,036C/T—uncertain significance
rs617487524:57,777,038T/G—benign
rs13426335624:57,777,042G/A—uncertain significance
rs7474811994:57,777,043G/A—uncertain significance
rs7751234714:57,777,062T/C—likely benign
rs15784853244:57,777,068A/G—likely benign
rs7961544754:57,777,070A/G—uncertain significance
rs617487534:57,777,078G/T—pathogenic
rs17198678974:57,777,086A/G—likely benign
rs9774277954:57,777,093G/A—uncertain significance
rs7617579854:57,777,094C/T—uncertain significance
rs13231499274:57,777,097A/G—uncertain significance
rs1398403434:57,777,098T/A—benign
rs1416315184:57,777,100T/C—uncertain significance
rs3737074774:57,777,104A/G—likely benign
rs1504128774:57,777,106G/A—uncertain significance
rs13564419174:57,777,111C/A—uncertain significance
rs7518944764:57,777,112C/G—uncertain significance
rs7509985654:57,777,119A/C—likely benign
rs24757985424:57,777,126A/G—uncertain significance
rs1381442084:57,777,128C/T—likely benign
rs7717801144:57,777,140A/G—likely benign
rs14580859914:57,777,152C/T—likely benign
rs3767370374:57,777,155C/T—likely benign
rs9402454204:57,777,156G/A—uncertain significance
rs7478614674:57,777,158C/T—likely benign
rs1491119114:57,777,167T/C—likely benign
rs1498292504:57,777,171C/G—likely benign
rs17198774134:57,777,174G/C—uncertain significance
rs13521646944:57,777,184C/T—uncertain significance
rs17198787194:57,777,189G/A—likely benign
rs5497960774:57,777,190G/T—uncertain significance
rs24757988704:57,777,191T/C—likely benign
rs13365677194:57,777,195C/A—uncertain significance
rs1457465194:57,777,212A/T—likely benign
rs3746144064:57,777,216A/G—uncertain significance
rs13585945874:57,777,217A/G—uncertain significance
rs1121155004:57,777,220A/G—uncertain significance
rs17198815674:57,777,223T/G—uncertain significance
rs1386866724:57,777,226C/G—uncertain significance
rs13870360634:57,777,227C/T—likely benign
rs7635635994:57,777,229C/G—uncertain significance
rs7719349234:57,777,230T/C—likely benign
rs13104299134:57,777,244C/T—uncertain significance
rs5469254914:57,777,245G/A—likely benign
rs13710928504:57,777,261A/G—uncertain significance
rs9933860634:57,777,263C/T—likely benign
rs5324512684:57,777,299A/G—benign
rs11784553024:57,777,328T/C—uncertain significance
rs3757351724:57,777,331A/G—uncertain significance
rs21095243654:57,777,332T/C—likely benign
rs7667630314:57,777,336A/T—uncertain significance
rs24757995364:57,777,337T/A—uncertain significance
rs7648155204:57,777,360T/C—uncertain significance
rs12332799284:57,777,380A/G—likely benign
rs7458766534:57,777,397C/T—uncertain significance
rs7685653704:57,777,399A/G—uncertain significance
rs21095245884:57,777,408G/T—uncertain significance
rs3697892874:57,777,412C/G—uncertain significance
rs11736818744:57,777,415C/G—uncertain significance
rs5547806094:57,777,416C/T—likely benign
rs9816395764:57,777,417A/C—uncertain significance
rs7734589774:57,777,418C/T—uncertain significance
rs3736917874:57,777,420G/C—uncertain significance
rs1379611734:57,777,422A/C—likely benign
rs21095246824:57,777,425A/G—likely benign
rs21095247654:57,777,441A/C—uncertain significance

Showing 100 of 534 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.